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Nlrp4e Gene Detail
Summary
  • Symbol
    Nlrp4e
  • Name
    NLR family, pyrin domain containing 4E
  • Synonyms
    4930406H16Rik, Nalp4e, Nalp-epsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:3056600
    NCBI Gene: 446099
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:23000617-23061702 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 10.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1867 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3056600
 protein coding gene Chr7:23000617-23061702 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031806
 protein coding gene Chr7:21427827-21496962 (+)
A/J MGP_AJ_G0031782
 protein coding gene Chr7:21035280-21045057 (+)
AKR/J MGP_AKRJ_G0031708
 protein coding gene Chr7:21542145-21549546 (+)
BALB/cJ MGP_BALBcJ_G0031787
 protein coding gene Chr7:21247114-21254033 (+)
C3H/HeJ MGP_C3HHeJ_G0031509
 protein coding gene Chr7:21855510-21874370 (+)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030852
 protein coding gene Chr7:15457641-15465100 (+)
CBA/J MGP_CBAJ_G0031471
 protein coding gene Chr7:23020812-23028533 (+)
DBA/2J MGP_DBA2J_G0031626
 protein coding gene Chr7:20975570-20982788 (+)
FVB/NJ MGP_FVBNJ_G0031578
 protein coding gene Chr7:20885252-20950856 (+)
LP/J MGP_LPJ_G0031708
 protein coding gene Chr7:21839883-21848341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031614
 protein coding gene Chr7:22900192-22911029 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032281
 protein coding gene Chr7:21241062-21251937 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030952
 protein coding gene Chr7:21432894-21439589 (+)



Homology
more
  • Human Ortholog
    NLRP4, NLR family pyrin domain containing 4
  • Vertebrate Orthologs
    101
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP4, NLR family pyrin domain containing 4
  • Synonyms
    CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
  • Links
    NCBI Gene ID: 147945
    neXtProt AC: NX_Q96MN2
    UniProt: Q96MN2

  • Chr Location
    19q13.43; chr19:55836540-55881855 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    8
  • cDNA Data
    7
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 446099 NCBI Gene Model | MGI Sequence Detail 61086 C57BL/6J ±  kb
transcript NM_001004194 RefSeq | MGI Sequence Detail 3382 C57BL/6  
polypeptide Q66X19 UniProt | EBI | MGI Sequence Detail 978 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011566 NACHT, LRR and PYD domains-containing protein 4E
    (term hierarchy)
  • InterPro Domains
    IPR004020 DAPIN domain
    IPR011029 Death-like domain superfamily
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
    IPR007111 NACHT nucleoside triphosphatase
    IPR050637 NLRP family, innate immunity and inflammation regulators
    IPR041075 NOD2, winged helix domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:1925402
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory