Tg(FCGR2A)11Mkz
Transgene Detail

Summary

• Symbol: Tg(FCGR2A)11Mkz
• Name: transgene insertion 11, Steven E McKenzie
• MGI ID: MGI:3056729
• Synonyms: FcgammaRIIA^TGN, huFCGR2A^R131
• Transgene: Tg(FCGR2A)11Mkz Location: unknown
• Alliance: Tg(FCGR2A)11Mkz page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(FCGR2A)11Mkz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FCGR2A (2212)

  Fcgr2b	(MGI:95499)
  Fcgr3	(MGI:95500)

• Mutation details: The transgene contains the human FCGR2A gene. The genomic clone used in the transgene encodes the R¹³¹ polymorphic form of human FcgRIIA, which binds the widest range of mouse IgG subclasses including mouse IgG1 and rat IgG2a as well. 10 copies of the transgene was estimated to have inserted into the genome. Transgenic mice express human FCGR2A on mouse platelets and macrophages at levels equivalent to that observed in human cells. (J:93244, J:136516)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:93244 McKenzie SE, et al., The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model. J Immunol. 1999 May 1;162(7):4311-8
• All: 46 reference(s)