Tg(Igh-6/Igh-V281)3Jwt
Transgene Detail

Summary

• Symbol: Tg(Igh-6/Igh-V281)3Jwt
• Name: transgene insertion 3, James W Thomas
• MGI ID: MGI:3056939
• Synonyms: 281HC, H125.gl, VH281, VH281Tg
• Transgene: Tg(Igh-6/Igh-V281)3Jwt Location: unknown
• Alliance: Tg(Igh-6/Igh-V281)3Jwt page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-6/Igh-V281)3Jwt expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igh-V (MGI:96477)
  mouse	Ighm (MGI:96448)

• Mutation details: The construct for Tg(Igh-6/Igh-V281)3Jwt has a germ line reversion encoding D at residue 49 (from G)and another encoding V (from E) at residue 56. The transgene encodes an IgM^a constant region with a variable region nearly identical to that of the BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125, (from the American Type Culture Collection) but lacking the high affinity specificity for insulin. (J:91865)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:91865 Hulbert C, et al., B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol. 2001 Nov 15;167(10):5535-8
• All: 3 reference(s)