Tg(Igk-C/Igk-V125)1Jwt
Transgene Detail

Summary

• Symbol: Tg(Igk-C/Igk-V125)1Jwt
• Name: transgene insertion 1, James W Thomas
• MGI ID: MGI:3057119
• Synonyms: VK125, VK125-Ck, Vk125Tg, Vkappa125Tg
• Transgene: Tg(Igk-C/Igk-V125)1Jwt Location: unknown
• Alliance: Tg(Igk-C/Igk-V125)1Jwt page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igk-C/Igk-V125)1Jwt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ighg1 (MGI:96446)

• Mutation details: The transgene encodes a light chain that, when co-expressed with a transgene encoding the heavy chain with the VDJ of mAB125, binds most mammalian insulins. The source of the immunoglobulin kappa chain VJ sequence in this transgene was the BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125 (from the American Type Culture Collection). (J:91865)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:91865 Hulbert C, et al., B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol. 2001 Nov 15;167(10):5535-8
• All: 7 reference(s)