Tg(MAPT)8cPdav
Transgene Detail

Summary

• Symbol: Tg(MAPT)8cPdav
• Name: transgene insertion 8c, Peter Davies
• MGI ID: MGI:3057129
• Synonyms: 8c, hTau
• Transgene: Tg(MAPT)8cPdav Location: unknown
• Alliance: Tg(MAPT)8cPdav page

Beta-amyloid plaques in Tg(APPswe,PSEN1dE9)85Dbo/0 mice and neurofibrillary tangles in Mapt^tm1(EGFP)Klt/Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Swiss Webster x (C57BL/6 x DBA)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Tg(MAPT)8cPdav involves 1 genes/genome features (Trim30d) View all
• Tg(MAPT)8cPdav expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The transgene contains the coding sequence, intronic regions, and regulatory elements of the human microtubule-associated protein tau (MAPT) gene. Tg(MAPT)8cPdav integrated on chromosome 7 [104,477,768-104,477,769 ; mm10] in an intron of the tripartite motif-containing 30D locus (Trim30d). The transgene copy number was not calculated. It was not determined if this resulted in any genomic duplication(s) or if this alters endogenous Trim30d expression. (J:85952, J:276927)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Mice that are homozygous for the Mapt^tm1(GFP)Klt allele and hemizygous for the transgene are viable and fertile. Although no endogenous mouse MAPT is detected, all six isoforms (including both 3R and 4R forms) of human MAPT are expressed. Hyperphosphorylated MAPT is detected in cell bodies and dendrites by 3 months of age. Paired helical filaments of aggregated insoluble MAPT can be isolated from brain tissue as early as 2 months of age.

References

• Original: J:85952 Duff K, et al., Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis. 2000 Apr;7(2):87-98
• All: 104 reference(s)