Tg(SKP2)4Paga
Transgene Detail

Summary

• Symbol: Tg(SKP2)4Paga
• Name: transgene insertion 4, Michele Pagano
• MGI ID: MGI:3057133
• Synonyms: CD4-SKP2
• Transgene: Tg(SKP2)4Paga Location: unknown
• Alliance: Tg(SKP2)4Paga page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SKP2)4Paga expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SKP2 (6502)

  Skp2	(MGI:1351663)

• Mutation details: The transgene contains the human SKP2 gene and the mouse Cd4 minimal promoter/enhancer. Transgene expression occurs in thymus and peripheral lymphoid organs. (J:67474)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(SKP2)4Paga/0	involves: C57BL/6 * DBA/2

Phenotypes:

Affected Systems	tg1
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normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:67474 Latres E, et al., Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2515-20
• All: 1 reference(s)