Tg(Prnp-SNCA*A53T)83Vle
Transgene Detail

Summary

• Symbol: Tg(Prnp-SNCA*A53T)83Vle
• Name: transgene insertion 83, Virginia M-Y Lee
• MGI ID: MGI:3057167
• Synonyms: A53T alpha-synuclein PRP, alphaS⁺, M83, Prp-alphaSyn^A53T, PrP-alpha-syn mice (line M83), Tg(SNCA)83Vle
• Transgene: Tg(Prnp-SNCA*A53T)83Vle Location: Chr12:48259499-48259500 bp Genetic Position: Chr12, Syntenic
• Alliance: Tg(Prnp-SNCA*A53T)83Vle page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-SNCA*A53T)83Vle expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The transgene contains the mouse prion protein promoter, its 5' and 3' untranslated regions, and a human alpha synuclein cDNA sequence encoding a mutated protein with an Ala53Thr mutation. Transgene expression was detected in the cerebral cortex, spinal cord, and cerebellum. Transgene insertion occurred on Chr 12. (J:76657)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This line was originally designated M83. Line M91 was also generated.

References

• Original: J:76657 Giasson BI, et al., Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 2002 May 16;34(4):521-33
• All: 142 reference(s)