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Apcdd1 Gene Detail
Summary
  • Symbol
    Apcdd1
  • Name
    adenomatosis polyposis coli down-regulated 1
  • Synonyms
    Drapc1, EIG180
  • Feature Type
    protein coding gene
  • IDs
    MGI:3513977
    NCBI Gene: 494504
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:63055398-63086886 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 35.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    889 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3513977
 protein coding gene Chr18:63055302-63094250 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024496
 protein coding gene Chr18:62879200-62909347 (+)
A/J MGP_AJ_G0024463
 protein coding gene Chr18:60199606-60230951 (+)
AKR/J MGP_AKRJ_G0024433
 protein coding gene Chr18:61855815-61886071 (+)
BALB/cJ MGP_BALBcJ_G0024462
 protein coding gene Chr18:60335503-60366121 (+)
C3H/HeJ MGP_C3HHeJ_G0024230
 protein coding gene Chr18:62099016-62132138 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024909
 protein coding gene Chr18:64588211-64619692 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022340
 protein coding gene Chr18:59705925-59735998 (+)
CAST/EiJ MGP_CASTEiJ_G0023703
 protein coding gene Chr18:61973758-62005861 (+)
CBA/J MGP_CBAJ_G0024200
 protein coding gene Chr18:66688256-66722802 (+)
DBA/2J MGP_DBA2J_G0024330
 protein coding gene Chr18:59852121-59882263 (+)
FVB/NJ MGP_FVBNJ_G0024296
 protein coding gene Chr18:59250991-59281073 (+)
LP/J MGP_LPJ_G0024414
 protein coding gene Chr18:62765756-62797599 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024325
 protein coding gene Chr18:68213423-68243575 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024956
 protein coding gene Chr18:62068807-62100509 (+)
PWK/PhJ MGP_PWKPhJ_G0023446
 protein coding gene Chr18:60091623-60122394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023251
 protein coding gene Chr18:62276299-62306355 (+)
WSB/EiJ MGP_WSBEiJ_G0023767
 protein coding gene Chr18:61922665-61953476 (+)



Homology
more
  • Human Ortholog
    APCDD1, APC down-regulated 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APCDD1, APC down-regulated 1
  • Synonyms
    B7323, DRAPC1, FP7019, HHS, HTS, HYPT1
  • Links
    NCBI Gene ID: 147495
    neXtProt AC: NX_Q8J025
    UniProt: Q8J025

  • Chr Location
    18p11.22
Human Diseases
more
  • Diseases
    1 with human APCDD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    116
  • cDNA Data
    57
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 494504 NCBI Gene Model | MGI Sequence Detail 31489 C57BL/6J ±  kb
    transcript NM_133237 RefSeq | MGI Sequence Detail 3419 C57BL/6  
    polypeptide Q3U128 UniProt | EBI | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 57
      Primer pair 2
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147323, MGI:2181620
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 28
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:353315 Ding W, et al., Adaptive functions of structural variants in human brain development. Sci Adv. 2024 Apr 5;10(14):eadl4600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory