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Trpa1 Gene Detail
Summary
  • Symbol
    Trpa1
  • Name
    transient receptor potential cation channel, subfamily A, member 1
  • Synonyms
    ANKTM1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3522699
    NCBI Gene: 277328
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:14942872-14989086 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 4.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1891 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3522699
 protein coding gene Chr1:14942868-14989086 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015847
 protein coding gene Chr1:12326250-12375292 (-)
A/J MGP_AJ_G0015829
 protein coding gene Chr1:12199247-12247621 (-)
AKR/J MGP_AKRJ_G0015788
 protein coding gene Chr1:12186478-12232927 (-)
BALB/cJ MGP_BALBcJ_G0015785
 protein coding gene Chr1:11905222-11953841 (-)
C3H/HeJ MGP_C3HHeJ_G0015619
 protein coding gene Chr1:12178419-12224430 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016239
 protein coding gene Chr1:12864214-12911412 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013960
 protein coding gene Chr1:10770785-10817337 (-)
CAST/EiJ MGP_CASTEiJ_G0015199
 protein coding gene Chr1:12301180-12349375 (-)
CBA/J MGP_CBAJ_G0015592
 protein coding gene Chr1:13160408-13212229 (-)
DBA/2J MGP_DBA2J_G0015691
 protein coding gene Chr1:11824410-11871485 (-)
FVB/NJ MGP_FVBNJ_G0015696
 protein coding gene Chr1:11617013-11664196 (-)
LP/J MGP_LPJ_G0015763
 protein coding gene Chr1:12523151-12570474 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015715
 protein coding gene Chr1:13864161-13912579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016286
 protein coding gene Chr1:12116249-12163990 (-)
PWK/PhJ MGP_PWKPhJ_G0014983
 protein coding gene Chr1:11630620-11678063 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014764
 protein coding gene Chr1:12331359-12378870 (-)
WSB/EiJ MGP_WSBEiJ_G0015263
 protein coding gene Chr1:12093433-12145636 (-)



Homology
more
  • Human Ortholog
    TRPA1, transient receptor potential cation channel subfamily A member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPA1, transient receptor potential cation channel subfamily A member 1
  • Synonyms
    ANKTM1, FEPS, FEPS1, p120
  • Links
    NCBI Gene ID: 8989
    neXtProt AC: NX_O75762
    UniProt: O75762

  • Chr Location
    8q21.11; chr8:72019917-72090010 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRPA1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 8 alleles in 7 genetic backgrounds
    238 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    58
  • cDNA Data
    8
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032769 Ensembl Gene Model | MGI Sequence Detail 46215 C57BL/6J ±  kb
    transcript ENSMUST00000041447 Ensembl | MGI Sequence Detail 4263 Not Applicable  
    polypeptide ENSMUSP00000043594 Ensembl | MGI Sequence Detail 1125 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 8
      Primer pair 2
      Other 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 327
      Developmental Gene Expression 20
      Gene Ontology 19
      Phenotypes 238
    • Earliest
      J:96171 Story GM, et al., ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29
    • Latest
      J:354852 Singh K, et al., The IgLON family of cell adhesion molecules expressed in developing neural circuits ensure the proper functioning of the sensory system in mice. Sci Rep. 2024 Sep 30;14(1):22593
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory