Nstr1 QTL Detail

Summary

• Symbol
  Nstr1
• Name
  nerve sheath tumor resistance QTL 1

• Feature Type
  QTL
• IDs
  MGI:3524871
  NCBI Gene: 100035039

Location &
Maps

• Sequence Map
  Chr19:5371140-5371338 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 4.30 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from multigenic genotypes
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a null allele exhibit decreased antinociception, body temperature reduction, impaired coordination and hypoperistalsis in response to neurotensin 2.

Sequences &
Gene Models

• NCBI Gene
  100035039

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:105038 Reilly KM, et al., An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model. Cancer Res. 2006 Jan 1;66(1):62-8
• Latest
  J:147432 Walrath JC, et al., Chr 19(A/J) modifies tumor resistance in a sex- and parent-of-origin-specific manner. Mamm Genome. 2009 Apr;20(4):214-23