Tg(Igh-6/Igh-V125)2Jwt
Transgene Detail

Summary

• Symbol: Tg(Igh-6/Igh-V125)2Jwt
• Name: transgene insertion 2, James W Thomas
• MGI ID: MGI:3526723
• Synonyms: 125HC, 125Tg, 125VH, VH125, VH125Tg, VH Tg125
• Transgene: Tg(Igh-6/Igh-V125)2Jwt Location: unknown
• Alliance: Tg(Igh-6/Igh-V125)2Jwt page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-6/Igh-V125)2Jwt expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igh-V (MGI:96477)
  mouse	Ighm (MGI:96448)

• Mutation details: This construct encodes an IgM^a constant region with the variable specificity from BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125 that was the source of the immunoglobulin heavy chain VDJ sequence in this transgene. The resulting antibody binds insulin when co-expressed with a transgene encoding the light chain with the VJ of mAB125. (J:91866)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:91866 Rojas M, et al., Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen. J Immunol. 2001 Mar 1;166(5):3194-200
• All: 13 reference(s)