Tg(PDGFB-SNCA)4Ema
Transgene Detail

Summary

• Symbol: Tg(PDGFB-SNCA)4Ema
• Name: transgene insertion 4, Eliezer Masliah
• MGI ID: MGI:3528873
• Synonyms: line D, PDGFbeta-alpha-syn
• Transgene: Tg(PDGFB-SNCA)4Ema Location: unknown
• Alliance: Tg(PDGFB-SNCA)4Ema page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-SNCA)4Ema expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The transgene contains human platelet derived growth factor, B polypeptide (PDGFB) promoter, an SV40 splice site, 423 bp of human cDNA encoding full length wild-type alpha synuclein (SNCA), and SV40 polyadenylation sequences. (J:60638)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This line, which showed the highest transgene expression levels, was originally designated line D. Line C, which showed the lowest transgene expression levels, and lines A, B, and M were also generated.

References

• Original: J:60638 Masliah E, et al., Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science. 2000 Feb 18;287(5456):1265-9
• All: 34 reference(s)