Tg(SOD1*G37R)42Dpr
Transgene Detail

Summary

• Symbol: Tg(SOD1*G37R)42Dpr
• Name: transgene insertion 42, Donald L Price
• MGI ID: MGI:3574014
• Synonyms: G37R(42), G37R SOD1 line 42, SOD1 G37R line 42, Tg(SOD1-G37R)42Dpr
• Transgene: Tg(SOD1*G37R)42Dpr Location: unknown
• Alliance: Tg(SOD1*G37R)42Dpr page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*G37R)42Dpr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: A 12 kb genomic DNA fragment containing a mutated form of human SOD1 with a glycine to arginine substitution at amino acid 37 (G37R) was used for the transgene. The G37R mutation is found in some cases of familial amyotrophic lateral sclerosis (FALS). (J:69178)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:69178 Wong PC, et al., An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron. 1995 Jun;14(6):1105-16
• All: 24 reference(s)