Tg(Msmb-TAg)186-3Xuan
Transgene Detail

Summary

• Symbol: Tg(Msmb-TAg)186-3Xuan
• Name: transgene insertion 186-3, JW Xuan
• MGI ID: MGI:2448149
• Synonyms: TGMAP
• Transgene: Tg(Msmb-TAg)186-3Xuan Location: unknown
• Alliance: Tg(Msmb-TAg)186-3Xuan page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgenic construct contained a 3842 bp Msmb promoter/enhancer fragment, exon 1, a 1.2 kb 5' portion of intron 1 followed by a 0.6 kb 3'portion of intron 1, followed by sequence encoding the SV40 large and small T antigens. The Msmb promoter/enhancer fragment drove expression in the ventral and dorsolateral prostate lobes. (J:80313)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Msmb-TAg)186-3Xuan

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Southern blot analysis indicated that this line carries approximately 150 copies of the transgenic construct.

References

• Original: J:80313 Gabril MY, et al., Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model. Gene Ther. 2002 Dec;9(23):1589-99
• All: 10 reference(s)