Sp9 MGI Mouse Gene Detail - MGI:3574660 - trans-acting transcription factor 9

Symbol

Sp9
Name

trans-acting transcription factor 9

Feature Type

protein coding gene
IDs

MGI:3574660
NCBI Gene: 381373
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:73094809-73106115 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 43.52 cM
Mapping Data

1 experiment

SNPs within 2kb

193 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3574660	protein coding gene	Chr2:73094809-73115050 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025834	protein coding gene	Chr2:73540836-73553617 (+)
A/J	MGP_AJ_G0025812	protein coding gene	Chr2:70653591-70659137 (+)
AKR/J	MGP_AKRJ_G0025780	protein coding gene	Chr2:72591469-72604355 (+)
BALB/cJ	MGP_BALBcJ_G0025806	protein coding gene	Chr2:70841404-70853799 (+)
C3H/HeJ	MGP_C3HHeJ_G0025566	protein coding gene	Chr2:72780105-72794479 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026253	protein coding gene	Chr2:75733840-75746891 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023656	protein coding gene	Chr2:67855319-67868049 (+)
CAST/EiJ	MGP_CASTEiJ_G0025030	protein coding gene	Chr2:73041028-73056471 (+)
CBA/J	MGP_CBAJ_G0025547	protein coding gene	Chr2:78504537-78517298 (+)
DBA/2J	MGP_DBA2J_G0025678	protein coding gene	Chr2:70250402-70262673 (+)
FVB/NJ	MGP_FVBNJ_G0025640	protein coding gene	Chr2:69664164-69669710 (+)
LP/J	MGP_LPJ_G0025766	protein coding gene	Chr2:73417610-73430493 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025671	protein coding gene	Chr2:80435499-80441045 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026310	protein coding gene	Chr2:72678205-72683751 (+)
PWK/PhJ	MGP_PWKPhJ_G0024771	protein coding gene	Chr2:70166289-70179118 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024579	protein coding gene	Chr2:72913909-72926669 (+)
WSB/EiJ	MGP_WSBEiJ_G0025098	protein coding gene	Chr2:73125656-73131206 (+)

Human Ortholog

SP9, Sp9 transcription factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SP9, Sp9 transcription factor
Synonyms

ZNF990
Links

HGNC:30690

NCBI Gene ID: 100131390

neXtProt AC: NX_P0CG40

UniProt: P0CG40
Chr Location

2q31.1; chr2:174334954-174338500 (+) GRCh38

MGI Vertebrate Homology

Sp9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SP9
Gene Tree

Sp9

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Phenotype Summary

10 phenotypes from 2 alleles in 1 genetic background
2 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

11
Genomic Mutations

7 involving Sp9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele fail to thrive and exhibit general weakness and postnatal lethality associated with striatum atrophy and loss of striatopallidal medium-sized spiny neurons (MSNs) due to decreased proliferation of striatopallidal MSN progenitors and increased apoptosis.

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All GO Annotations

9
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

20
cDNA Data

10
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sp9

ZFIN sp9

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS16126.1

Ensembl

ENSMUSG00000068859 (Evidence)
NCBI Gene

381373

			Length	Strain/Species	Flank
genomic	381373	NCBI Gene Model \| MGI Sequence Detail	11307	C57BL/6J	± kb
transcript	NM_001409583	RefSeq \| MGI Sequence Detail	3680	C57BL/6
polypeptide	Q64HY3	UniProt \| EBI \| MGI Sequence Detail	484	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031727 transcription factor Sp9

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 15

Genomic 1

cDNA 11

Primer pair 1

Other 2

Microarray probesets 1

Summaries

All 64

Developmental Gene Expression 28

Gene Ontology 7

Phenotypes 23
Earliest

J:95649 Kawakami Y, et al., Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos. Development. 2004 Oct;131(19):4763-74
Latest

J:341393 Cheffer A, et al., DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. Cereb Cortex. 2023 Sep 26;33(19):10272-10285

TSS for Sp9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18368	Chr2:73098341-73098349 (+)	3,536 bp
Tssr18369	Chr2:73102270-73102283 (+)	7,468 bp
Tssr18370	Chr2:73102291-73102303 (+)	7,488 bp
Tssr18371	Chr2:73104610-73104651 (+)	9,822 bp
Tssr18372	Chr2:73105057-73105069 (+)	10,254 bp
Tssr18373	Chr2:73105075-73105093 (+)	10,275 bp
Tssr18374	Chr2:73105143-73105152 (+)	10,339 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24