Ugt1a9 MGI Mouse Gene Detail - MGI:3576092 - UDP glucuronosyltransferase 1 family, polypeptide A9

Symbol

Ugt1a9
Name

UDP glucuronosyltransferase 1 family, polypeptide A9
Synonyms

A12, mUGTBr/P

Feature Type

protein coding gene
IDs

MGI:3576092
NCBI Gene: 394434
Member of

Ugt1 cluster
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:87998522-88146719 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 44.50 cM
Mapping Data

1 experiment

SNPs within 2kb

3988 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3576092	protein coding gene	Chr1:87998501-88147724 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016274	protein coding gene	Chr1:89466460-89628377 (+)
A/J	MGP_AJ_G0016255	protein coding gene	Chr1:86127150-86334105 (+)
AKR/J	MGP_AKRJ_G0016216	protein coding gene	Chr1:88674880-88898479 (+)
BALB/cJ	MGP_BALBcJ_G0016212	protein coding gene	Chr1:86282384-86472410 (+)
C3H/HeJ	MGP_C3HHeJ_G0016040	protein coding gene	Chr1:88942345-89122337 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016670	protein coding gene	Chr1:92790594-92996654 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0015626	protein coding gene	Chr1:88151503-88339172 (+)
CBA/J	MGP_CBAJ_G0016016	protein coding gene	Chr1:95782859-95995691 (+)
DBA/2J	MGP_DBA2J_G0016119	protein coding gene	Chr1:85409777-85575533 (+)
FVB/NJ	MGP_FVBNJ_G0016118	protein coding gene	Chr1:84489356-84658645 (+)
LP/J	MGP_LPJ_G0016190	protein coding gene	Chr1:90512205-90703609 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016144	protein coding gene	Chr1:99025621-99344396 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016712	protein coding gene	Chr1:88773432-88953948 (+)
PWK/PhJ	MGP_PWKPhJ_G0015412	protein coding gene	Chr1:84757033-84935762 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015192	protein coding gene	Chr1:87663200-87876017 (+)
WSB/EiJ	no annotation

Human Ortholog

UGT1A10, UDP glucuronosyltransferase family 1 member A10

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UGT1A10, UDP glucuronosyltransferase family 1 member A10
Synonyms

GNT1, hUG-BR1, UDPGT, UGT1, UGT1-01, UGT1.1, UGT1-10, UGT1.10, UGT-1A, UGT1A, UGT1A1, UGT-1J, UGT1J
Links

HGNC:12531

NCBI Gene ID: 54575

neXtProt AC: NX_Q9HAW8

UniProt: Q9HAW8
Chr Location

2q37.1; chr2:233636448-233773300 (+) GRCh38

Human Ortholog

UGT1A7, UDP glucuronosyltransferase family 1 member A7
Synonyms

GNT1, hUG-BR1, UDPGT, UDPGT 1-7, UGT1, UGT1-01, UGT1-07, UGT1.1, UGT1.7, UGT-1A, UGT1A, UGT1A1, UGT-1G, UGT1G
Links

HGNC:12539

NCBI Gene ID: 54577

neXtProt AC: NX_Q9HAW7

UniProt: Q9HAW7
Chr Location

2q37.1; chr2:233681901-233773300 (+) GRCh38

Human Ortholog

UGT1A8, UDP glucuronosyltransferase family 1 member A8
Synonyms

GNT1, hUG-BR1, UDPGT, UDPGT 1-1, UDPGT 1-8, UGT1, UGT1-01, UGT1-08, UGT1.1, UGT1.8, UGT-1A, UGT1A, UGT1A1, UGT1A8S, UGT-1H, UGT1H
Links

HGNC:12540

NCBI Gene ID: 54576

neXtProt AC: NX_Q9HAW9

UniProt: Q9HAW9
Chr Location

2q37.1; chr2:233617633-233773300 (+) GRCh38

Human Ortholog

UGT1A9, UDP glucuronosyltransferase family 1 member A9
Synonyms

HLUGP4, LUGP4, UDPGT, UDPGT 1-9, UGT1-09, UGT1-9, UGT1.9, UGT1A9S, UGT1AI, UGT-1I, UGT1I
Links

HGNC:12541

NCBI Gene ID: 54600

neXtProt AC: NX_O60656

UniProt: O60656
Chr Location

2q37.1; chr2:233671898-233773300 (+) GRCh38

MGI Vertebrate Homology

Ugt1a9 stringent orthology
4 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: UGT1A10, UGT1A7, UGT1A8, UGT1A9
Gene Tree

Ugt1a9

Diseases

2 with human UGT1A7 associations

				Human Disease	Mouse Models
				alcoholic pancreatitis IDs alcoholic pancreatitis DOID:4988 MESH:D019512 UMLS_CUI:C0376670
				pancreatic cancer IDs pancreatic cancer DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Radiation induced

1
Genomic Mutations

2 involving Ugt1a9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available

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All GO Annotations

38
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

4
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS15138.1

Ensembl

ENSMUSG00000090175 (Evidence)
NCBI Gene

394434

			Length	Strain/Species	Flank
genomic	ENSMUSG00000090175	Ensembl Gene Model \| MGI Sequence Detail	148198	C57BL/6J	± kb
transcript	ENSMUST00000073772	Ensembl \| MGI Sequence Detail	2190	Not Applicable
polypeptide	ENSMUSP00000073444	Ensembl \| MGI Sequence Detail	528	Not Applicable

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UniProt

1 Sequence
EC

2.4.1.17
InterPro Domains

IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase

IPR050271 UDP-glycosyltransferase

IPR035595 UDP-glycosyltransferase family, conserved site
GlyGen

Q62452 3 sites

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All nucleic 5

cDNA 5

Microarray probesets 2

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 4
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Ugt1a9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7927	Chr1:87998449-87998468 (+)	-63 bp
Tssr7928	Chr1:87998475-87998482 (+)	-43 bp
Tssr7929	Chr1:87998487-87998519 (+)	-19 bp
Tssr7930	Chr1:87998526-87998535 (+)	9 bp
Tssr7931	Chr1:88001471-88001518 (+)	2,973 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24