Tg(Ins2*Y16A)1Ell
Transgene Detail

Summary

• Symbol: Tg(Ins2*Y16A)1Ell
• Name: transgene insertion 1, John F Elliot
• MGI ID: MGI:3576358
• Synonyms: tg B:16 alanine, line B
• Transgene: Tg(Ins2*Y16A)1Ell Location: unknown
• Alliance: Tg(Ins2*Y16A)1Ell page

Transgene origin

• Strain of Origin: NOD/MrkTac

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2*Y16A)1Ell expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: This transgenic construct contains the rat insulin7 construct of the rat insulin 2 gene fused to a mutated preproinsulin II cDNA where the tyrosine at position 16 of the B chain was replaced with alanine. The transgene is expressed in pancreatic beta cells. (J:97755)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:97755 Nakayama M, et al., Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene. Ann N Y Acad Sci. 2004 Dec;1037:193-8
• All: 10 reference(s)