Itgad MGI Mouse Gene Detail - MGI:3578624

Symbol

Itgad
Name

integrin, alpha D
Synonyms

Cd11d

Feature Type

protein coding gene
IDs

MGI:3578624
NCBI Gene: 381924
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:127773105-127822988 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 70.00 cM
Mapping Data

1 experiment

SNPs within 2kb

1474 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3578624	protein coding gene	Chr7:127753548-127822988 (+)
129S1/SvImJ	ENSMUSG00200021552	protein coding gene	Chr7:114264477-114338652 (+)
A/J	ENSMUSG00195038013	protein coding gene	Chr7:118765196-118837195 (+)
AKR/J	ENSMUSG00220015963	protein coding gene	Chr7:112219590-112291591 (+)
BALB/cJ	ENSMUSG00180012188	protein coding gene	Chr7:115460429-115532415 (+)
C3H/HeJ	ENSMUSG00175013280	protein coding gene	Chr7:116187271-116259250 (+)
C57BL/6NJ	ENSMUSG00215029074	protein coding gene	Chr7:115463360-115535378 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030539	protein coding gene	Chr7:130184214-130231983 (+)
CAST/EiJ	ENSTCUG00005047943	protein coding gene	Chr7:118700231-118775169 (+)
CBA/J	ENSMUSG00210023086	protein coding gene	Chr7:115944335-116016346 (+)
DBA/2J	ENSMUSG00185039284	protein coding gene	Chr7:120257193-120329210 (+)
FVB/NJ	ENSMUSG00205015803	protein coding gene	Chr7:115900315-115967387 (+)
JF1/MsJ	ENSUMUG00000013688	protein coding gene	Chr7:125278847-125353083 (+)
LP/J	ENSMUSG00230052095	protein coding gene	Chr7:126363223-126419589 (+)
NOD/ShiLtJ	ENSMUSG00190015223	protein coding gene	Chr7:116093502-116160568 (+)
NZO/HlLtJ	ENSMUSG00225011161	protein coding gene	Chr7:124600510-124672488 (+)
PWK/PhJ	ENSLUMG00010034935	protein coding gene	Chr7:114437352-114506232 (+)
SPRET/EiJ	ENSMSPG00010011393	protein coding gene	Chr7:115695152-115764809 (+)
WSB/EiJ	ENSIUOG00005025677	protein coding gene	Chr7:116792360-116864265 (+)

Human Ortholog

ITGAD, integrin subunit alpha D

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITGAD, integrin subunit alpha D
Synonyms

ADB2, CD11D
Links

HGNC:6146

NCBI Gene ID: 3681

UniProt: Q13349
Chr Location

16p11.2; chr16:31393335-31426505 (+) GRCh38

MGI Vertebrate Homology

Itgad stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ITGAD
Gene Tree

Itgad

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

5
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

66 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit a reduced staphylococcal enterotoxin-induced T cell response.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase itgad

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All Sequences

50
RefSeq

8
UniProt

6
CCDS

CCDS21890.2, CCDS52411.1

Ensembl

ENSMUSG00000070369 (Evidence)
NCBI Gene

381924

			Length	Strain/Species	Flank
genomic	381924	NCBI Gene Model \| MGI Sequence Detail	49884	C57BL/6J	± kb
transcript	NM_001029872	RefSeq \| MGI Sequence Detail	3975	C57BL/6
polypeptide	Q3V0T4	UniProt \| EBI \| MGI Sequence Detail	1168	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001009 integrin alpha-D

(term hierarchy)
InterPro Domains

IPR013517 FG-GAP repeat

IPR013519 Integrin alpha beta-propellor

IPR000413 Integrin alpha chain

IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site

IPR013649 Integrin alpha, first immunoglubulin-like domain

IPR028994 Integrin alpha, N-terminal

IPR048285 Integrin alpha, second immunoglobulin-like domain

IPR048633 Integrin alpha-X-like, third Ig-like domain

IPR032695 Integrin domain superfamily

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A
GlyGen

Q3V0T4 13 sites, 1 O-linked glycan (1 site)

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All nucleic 6

cDNA 6

Microarray probesets 3

Summaries

All 37

Gene Ontology 8

Phenotypes 14
Earliest

J:90954 Wu H, et al., Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 1;173(1):297-306
Latest

J:347839 Hou L, et al., CD11a regulates hematopoietic stem and progenitor cells. Front Immunol. 2023;14:1219953

TSS for Itgad:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69401	Chr7:127773116-127773153 (+)	30 bp
Tssr69402	Chr7:127787727-127787729 (+)	14,623 bp
Tssr69403	Chr7:127802569-127802576 (+)	29,468 bp
Tssr69404	Chr7:127802593-127802603 (+)	29,493 bp
Tssr69405	Chr7:127802770-127802779 (+)	29,670 bp
Tssr2412	Chr7:127804943-127804966 (+)	31,850 bp
Tssr69406	Chr7:127805065-127805094 (+)	31,975 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24