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Ugt1a6b Gene Detail
Summary
  • Symbol
    Ugt1a6b
  • Name
    UDP glucuronosyltransferase 1 family, polypeptide A6B
  • Synonyms
    A9'
  • Feature Type
    protein coding gene
  • IDs
    MGI:3580629
    NCBI Gene: 394435
  • Member of
    Ugt1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:88030979-88146720 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3186 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3580629
 protein coding gene Chr1:88030974-88146725 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016282
 protein coding gene Chr1:89615532-89628377 (+)
A/J MGP_AJ_G0016258
 protein coding gene Chr1:86163433-86334105 (+)
AKR/J MGP_AKRJ_G0016219
 protein coding gene Chr1:88761301-88898487 (+)
BALB/cJ MGP_BALBcJ_G0016215
 protein coding gene Chr1:86329671-86472418 (+)
C3H/HeJ MGP_C3HHeJ_G0016043
 protein coding gene Chr1:88975081-89122343 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016673
 protein coding gene Chr1:92842928-92996660 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014391
 protein coding gene Chr1:80583529-80707873 (+)
CAST/EiJ MGP_CASTEiJ_G0015629
 protein coding gene Chr1:88190952-88339178 (+)
CBA/J MGP_CBAJ_G0016019
 protein coding gene Chr1:95831932-95995699 (+)
DBA/2J MGP_DBA2J_G0016122
 protein coding gene Chr1:85444817-85575533 (+)
FVB/NJ MGP_FVBNJ_G0016121
 protein coding gene Chr1:84521429-84658653 (+)
LP/J MGP_LPJ_G0016197
 protein coding gene Chr1:90688836-90703609 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0016715
 protein coding gene Chr1:88808838-88953954 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0015196
 protein coding gene Chr1:87776597-87876023 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    UGT1A6, UDP glucuronosyltransferase family 1 member A6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UGT1A6, UDP glucuronosyltransferase family 1 member A6
  • Synonyms
    GNT1, HLUGP, HLUGP1, hUG-BR1, UDPGT, UDPGT 1-6, UGT1, UGT1-01, UGT1-03, UGT1-05, UGT1-06, UGT1.1, UGT1.3, UGT1.5, UGT1.6, UGT-1A, UGT1A, UGT1A1, UGT1A3, UGT1A5, UGT1A6S, UGT-1C, UGT1C, UGT-1E, UGT1E, UGT-1F, UGT1F
  • Links
    NCBI Gene ID: 54578
    neXtProt AC: NX_P19224
    UniProt: P19224

  • Chr Location
    2q37.1; chr2:233691607-233773300 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human UGT1A6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    998
  • Tissues
    169
  • cDNA Data
    1
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 394435 NCBI Gene Model | MGI Sequence Detail 115742 C57BL/6J ±  kb
    transcript NM_201410 RefSeq | MGI Sequence Detail 2293 C57BL/6  
    polypeptide NP_958812 RefSeq | MGI Sequence Detail 531 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
      2.4.1.17
    • InterPro Domains
      IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
      IPR050271 UDP-glycosyltransferase
      IPR035595 UDP-glycosyltransferase family, conserved site
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2
    References
    more
    • Summaries
      All 22
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory