Tg(Ins1-EGFP/GH1)14Hara
Transgene Detail

Summary

• Symbol: Tg(Ins1-EGFP/GH1)14Hara
• Name: transgene insertion 14, Manami Hara
• MGI ID: MGI:3583654
• Synonyms: MIP-GFP, NOD-MIP-GFP
• Transgene: Tg(Ins1-EGFP/GH1)14Hara Location: unknown
• Alliance: Tg(Ins1-EGFP/GH1)14Hara page

Transgene origin

• Strain of Origin: NOD/ShiLtJ

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene comprises a DNA fragment containing the mouse insulin 1 promoter, extending from 8.5 kb upstream of the transcription initiation site to nucleotide +12, driving expression of a fusion gene joining the 7.6-kb coding region of the enhanced green fluorescent protein (EGFP) gene to a 2.1-kb fragment of the human growth hormone 1 gene that confers high-level expression. (J:99450)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Transgenic mice develop normally and exhibit glucose tolerance and pancreatic insulin levels similar to those of controls. Histological analysis reveals normal islet architecture and coexpression of insulin and EGFP (J:100005)

References

• Original: J:100005 Hara M, NOD transgenic mice with green fluorescent protein-labeled pancreatic beta cells. MGI Direct Data Submission. 2005
• All: 9 reference(s)