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Prdm14 Gene Detail
Summary
  • Symbol
    Prdm14
  • Name
    PR domain containing 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588194
    NCBI Gene: 383491
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:13183681-13197387 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 4.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    507 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588194
 protein coding gene Chr1:13183649-13197467 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015840
 protein coding gene Chr1:10479815-10493035 (-)
A/J MGP_AJ_G0015822
 protein coding gene Chr1:10451615-10464846 (-)
AKR/J MGP_AKRJ_G0015781
 protein coding gene Chr1:10367876-10381119 (-)
BALB/cJ MGP_BALBcJ_G0015778
 protein coding gene Chr1:10150785-10164042 (-)
C3H/HeJ MGP_C3HHeJ_G0015612
 protein coding gene Chr1:10347285-10361655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016232
 protein coding gene Chr1:10987612-11001104 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013953
 protein coding gene Chr1:9076649-9088084 (-)
CAST/EiJ MGP_CASTEiJ_G0015192
 protein coding gene Chr1:10513847-10528782 (-)
CBA/J MGP_CBAJ_G0015585
 protein coding gene Chr1:11231319-11247194 (-)
DBA/2J MGP_DBA2J_G0015684
 protein coding gene Chr1:10054590-10069059 (-)
FVB/NJ MGP_FVBNJ_G0015689
 protein coding gene Chr1:9887798-9901095 (-)
LP/J MGP_LPJ_G0015756
 protein coding gene Chr1:10663891-10679964 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015708
 protein coding gene Chr1:11946585-11959926 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016279
 protein coding gene Chr1:10272749-10293146 (-)
PWK/PhJ MGP_PWKPhJ_G0014976
 protein coding gene Chr1:9869116-9883910 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014757
 protein coding gene Chr1:10506108-10519286 (-)
WSB/EiJ MGP_WSBEiJ_G0015256
 protein coding gene Chr1:10292215-10308357 (-)



Homology
more
  • Human Ortholog
    PRDM14, PR/SET domain 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM14, PR/SET domain 14
  • Synonyms
    PFM11
  • Links
    NCBI Gene ID: 63978
    neXtProt AC: NX_Q9GZV8
    UniProt: Q9GZV8

  • Chr Location
    8q13.3; chr8:70051651-70071693 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRDM14 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 6 alleles in 11 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit decreased primordial germ cell numbers, absent germ cells, and sterility in both males and females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    124
  • cDNA Data
    5
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042414 Ensembl Gene Model | MGI Sequence Detail 13707 C57BL/6J ±  kb
    transcript ENSMUST00000047577 Ensembl | MGI Sequence Detail 2564 Not Applicable  
    polypeptide ENSMUSP00000044245 Ensembl | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 5
      Primer pair 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 9
      Gene Ontology 14
      Phenotypes 22
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:347094 Toriyama K, et al., DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells. BMC Genomics. 2024 Apr 5;25(1):344
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory