tmgc46 Gene Detail

Summary

• Symbol
  tmgc46
• Name
  Tennessee Mouse Genome Consortium 46
• Synonyms
  118TNE

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:3589214
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 16, Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  1
• Chemically induced (ENU)
  1
• Find Mice (IMSR)
  1 strains or lines available

Homozygotes for this ENU-induced mutation exhibit high frequency hearing loss, with absent brainstem auditory evoked potential at 32kHz and decreased brainstem auditory evoked potential at 8 and 16KHz.

References

• Summaries
  All 4

  Phenotypes 3
• Earliest
  J:112370 Habiby Kermany M, et al., Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen. Hear Res. 2006 Oct;220(1-2):76-86
• Latest
  J:166103 Jiao Y, et al., ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice. Genes Genet Syst. 2009 Jun;84(3):219-24