repro33 Gene Detail

Summary

• Symbol
  repro33
• Name
  reproductive mutant 33, JAX Reproductive Mutagenesis Program
• Synonyms
  538-5

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:3590183
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr16:32130840-97631495 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 16, Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  7 phenotype references
  

• All Mutations and Alleles
  7
• Chemically induced (ENU)
  1
• Targeted
  6
• Genomic Mutations
  6 involving repro33
• Find Mice (IMSR)
  0 strains or lines available

Homozygotes for this ENU-induced mutation exhibit male reproductive abnormalities including infertility, low sperm concentration, abnormally looped sperm tails resulting in impaired motility, and low seminal vesicle weight.

References

• Summaries
  All 7

  Phenotypes 7
• Earliest
  J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5:e11614
• Latest
  J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883