Tg(PRNP-APPSweInd)8Dwst
Transgene Detail

Summary

• Symbol: Tg(PRNP-APPSweInd)8Dwst
• Name: transgene insertion 8, David Westaway
• MGI ID: MGI:3589475
• Synonyms: APP-KM670/671NL+V717F, CRND8, Tg19959, Tg(APPSwInd)8Dwst, TgCRND8, Tg(PRNP-APP*Swe*Ind)8Dwst
• Transgene: Tg(PRNP-APPSweInd)8Dwst Location: unknown
• Alliance: Tg(PRNP-APPSweInd)8Dwst page

Increase in creatine deposits in hippocampus of Tg(PRNP-APPSweInd)8Dwst/0 mice with age

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C3H/HeJ x C57BL/6J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PRNP-APPSweInd)8Dwst expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Swedish and Indiana mutations.

• Mutation details: The transgene expresses the mutant human amyloid protein precursor APPSweInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the Syrian hamster prion protein promoter. Transgenic mice express the App protein in brain at approximately 5 times the level of control mice. High level production of the pathogenic Abeta42 form of the Abeta peptide is seen by three months of age. (J:69967)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:69967 Chishti MA, et al., Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem. 2001 Jun 15;276(24):21562-70
• All: 173 reference(s)