Tg(PDGFB-APPSweIndArc)48Lms
Transgene Detail

Summary

• Symbol: Tg(PDGFB-APPSweIndArc)48Lms
• Name: transgene insertion 48, Lennart Mucke
• MGI ID: MGI:3603941
• Synonyms: Arc48
• Transgene: Tg(PDGFB-APPSweIndArc)48Lms Location: unknown
• Alliance: Tg(PDGFB-APPSweIndArc)48Lms page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-APPSweIndArc)48Lms expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: These mice express human amyloid protein precursor bearing the Arctic (E22G) mutation, as well as the Swedish (K670N/M671L) and Indiana (V717F) mutations, under control of the human platelet derived growth factor, B polypeptide (PDGFB), promoter. ELISA demonstrated levels of APP and the Beta-secretase-generated C99 fragment, from which amyloid-Beta is cleaved, were higher in this line than Tg(PDGFB-APPSwIND)20Lms in hippocampus. (J:100954)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100954 Cheng IH, et al., Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat Med. 2004 Nov;10(11):1190-2
• All: 6 reference(s)