Tg(Prnp-MAPT*P301L)JNPL3Hlmc
Transgene Detail

Summary

• Symbol: Tg(Prnp-MAPT*P301L)JNPL3Hlmc
• Name: transgene insertion JNPL3, Mike Hutton
• MGI ID: MGI:3604148
• Synonyms: JNPL3, P301L, P301L tau 4R, tau (P301L), tau^P301L, Tg(Prnp-MAPT*P301L)3Hlmc
• Transgene: Tg(Prnp-MAPT*P301L)JNPL3Hlmc Location: unknown
• Alliance: Tg(Prnp-MAPT*P301L)JNPL3Hlmc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-MAPT*P301L)JNPL3Hlmc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The mouse prion protein promoter was used to drive expression of human microtubule-associated protein tau with a P301L substitution. Hemizygous mice mice expressed the protein at levels roughly equivalent to that of endogenous tau. A largely neuronal expression pattern was shown by in situ hybridization, with strongest signals in the cerebellum and hippocampus, followed by the thalamus, hypothalamus, spinal cord, brainstem and cortex. (J:63887)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

Notes

Microinjected into fertilized mouse C57BL/DBA2/SW eggs.

References

• Original: J:63887 Lewis J, et al., Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet. 2000 Aug;25(4):402-5
• All: 83 reference(s)