Ypel4 MGI Mouse Gene Detail - MGI:3605071

Symbol

Ypel4
Name

yippee like 4

Feature Type

protein coding gene
IDs

MGI:3605071
NCBI Gene: 241525
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:84564402-84568999 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM
Mapping Data

1 experiment

SNPs within 2kb

123 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3605071	protein coding gene	Chr2:84564355-84568999 (+)
129S1/SvImJ	ENSMUSG00200051001	protein coding gene	Chr2:81580825-81585422 (+)
A/J	ENSMUSG00195048558	protein coding gene	Chr2:81693782-81698372 (+)
AKR/J	ENSMUSG00220049885	protein coding gene	Chr2:81572460-81577050 (+)
BALB/cJ	ENSMUSG00180054595	protein coding gene	Chr2:81621623-81626213 (+)
C3H/HeJ	ENSMUSG00175051933	protein coding gene	Chr2:81761217-81765807 (+)
C57BL/6NJ	ENSMUSG00215052158	protein coding gene	Chr2:81665924-81670521 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023727	protein coding gene	Chr2:78945416-78950014 (+)
CAST/EiJ	ENSTCUG00005052265	protein coding gene	Chr2:81111822-81116426 (+)
CBA/J	ENSMUSG00210031836	protein coding gene	Chr2:81789116-81793706 (+)
DBA/2J	ENSMUSG00185057077	protein coding gene	Chr2:81617862-81622452 (+)
FVB/NJ	ENSMUSG00205048061	protein coding gene	Chr2:80999415-81004018 (+)
JF1/MsJ	ENSUMUG00000004321	protein coding gene	Chr2:81543530-81548147 (+)
LP/J	ENSMUSG00230039732	protein coding gene	Chr2:83368963-83373553 (+)
NOD/ShiLtJ	ENSMUSG00190039697	protein coding gene	Chr2:81658313-81662910 (+)
NZO/HlLtJ	ENSMUSG00225001947	protein coding gene	Chr2:91253455-91258052 (+)
PWK/PhJ	ENSLUMG00010046173	protein coding gene	Chr2:81558777-81563392 (+)
SPRET/EiJ	ENSMSPG00010051942	protein coding gene	Chr2:83456018-83460606 (+)
WSB/EiJ	ENSIUOG00005052856	protein coding gene	Chr2:81598154-81602763 (+)

Human Ortholog

YPEL4, yippee like 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YPEL4, yippee like 4
Links

HGNC:18328

NCBI Gene ID: 219539

UniProt: Q96NS1
Chr Location

11q12.1; chr11:57645087-57649944 (-) GRCh38

MGI Vertebrate Homology

Ypel4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: YPEL4
Gene Tree

Ypel4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

5
Genomic Mutations

3 involving Ypel4
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects erythrocyte morphology and leads to increased red blood cell concentration, clearance rate, size and size variation and reduced deformability.

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All GO Annotations

17
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
Tissues

34
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

42
RefSeq

6
UniProt

4
CCDS

CCDS16192.1

Ensembl

ENSMUSG00000034059 (Evidence)
NCBI Gene

241525

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034059	Ensembl Gene Model \| MGI Sequence Detail	4598	C57BL/6J	± kb
transcript	ENSMUST00000238573	Ensembl \| MGI Sequence Detail	1585	Not Applicable
polypeptide	ENSMUSP00000158708	Ensembl \| MGI Sequence Detail	158	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017545 protein yippee-like 4

(term hierarchy)
InterPro Domains

IPR034751 Yippee domain

IPR039058 Yippee family

IPR004910 Yippee/Mis18/Cereblon

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All nucleic 4

cDNA 4

Microarray probesets 1

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 16
Earliest

J:100298 Spitz F, et al., Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes. Nat Genet. 2005 Aug;37(8):889-93
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ypel4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18677	Chr2:84564394-84564451 (+)	21 bp
Tssr18678	Chr2:84568479-84568482 (+)	4,079 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24