Slc22a29 MGI Mouse Gene Detail - MGI:3605624 - solute carrier family 22. member 29

Symbol

Slc22a29
Name

solute carrier family 22. member 29
Synonyms

D630002G06Rik

Feature Type

protein coding gene
IDs

MGI:3605624
NCBI Gene: 236293
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr19:8137529-8196264 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.40 cM
Mapping Data

1 experiment

SNPs within 2kb

1251 from dbSNP Build 142
Strain Annotations

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3605624	protein coding gene	Chr19:8137529-8230739 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024799	protein coding gene	Chr19:5393278-5394608 (-)
A/J	MGP_AJ_G0024766	protein coding gene	Chr19:4679619-4732925 (-)
AKR/J	MGP_AKRJ_G0024742	protein coding gene	Chr19:5148659-5355635 (-)
BALB/cJ	MGP_BALBcJ_G0024766	protein coding gene	Chr19:4747971-4797225 (-)
C3H/HeJ	MGP_C3HHeJ_G0024533	protein coding gene	Chr19:5267533-5478315 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025214	protein coding gene	Chr19:5490923-5697310 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0024006	protein coding gene	Chr19:4891269-4892586 (-)
CBA/J	MGP_CBAJ_G0024506	protein coding gene	Chr19:5205056-5824277 (-)
DBA/2J	MGP_DBA2J_G0024633	protein coding gene	Chr19:4585093-4812253 (-)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0024719	protein coding gene	Chr19:4892721-4987151 (-)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0025260	protein coding gene	Chr19:4948207-5289386 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0023556	protein coding gene	Chr19:4735659-4743447 (-)
WSB/EiJ	MGP_WSBEiJ_G0024068	protein coding gene	Chr19:5150849-5152170 (-)

Human Ortholog

SLC22A10, solute carrier family 22 member 10

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A10, solute carrier family 22 member 10
Synonyms

hOAT5, OAT5
Links

HGNC:18057

NCBI Gene ID: 387775

neXtProt AC: NX_Q63ZE4

UniProt: Q63ZE4
Chr Location

11q12.3

Human Ortholog

SLC22A25, solute carrier family 22 member 25
Synonyms

HIMTP, UST6
Links

HGNC:32935

NCBI Gene ID: 387601

neXtProt AC: NX_Q6T423

UniProt: Q6T423
Chr Location

11q12.3; chr11:63158437-63243599 (-) GRCh38

Human Ortholog

SLC22A9, solute carrier family 22 member 9
Synonyms

HOAT4, OAT4, OAT7, ust3, UST3H
Links

HGNC:16261

NCBI Gene ID: 114571

neXtProt AC: NX_Q8IVM8

UniProt: Q8IVM8
Chr Location

11q12.3; chr11:63369785-63410294 (+) GRCh38

MGI Vertebrate Homology

Slc22a29 stringent orthology
3 human;1 mouse;2 rat
HCOP

vertebrate homology predictions: SLC22A10, SLC22A25, SLC22A9
Gene Tree

Slc22a29

Diseases

2 with human SLC22A9 associations

				Human Disease	Mouse Models
				Lynch syndrome IDs Lynch syndrome DOID:3883 DOID:0050586 DOID:3040 MESH:D003123 NCI:C8494 OMIM:PS120435 ORDO:144 UMLS_CUI:C0009405 UMLS_CUI:C4552100
				mismatch repair cancer syndrome IDs mismatch repair cancer syndrome DOID:0112182 OMIM:276300 ORDO:252202

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

12
cDNA Data

2
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

39
RefSeq

10
UniProt

4
CCDS

CCDS29535.1, CCDS84413.1

Ensembl

ENSMUSG00000075044 (Evidence)
NCBI Gene

236293

			Length	Strain/Species	Flank
genomic	ENSMUSG00000075044	Ensembl Gene Model \| MGI Sequence Detail	58736	C57BL/6J	± kb
transcript	ENSMUST00000113298	Ensembl \| MGI Sequence Detail	2271	Not Applicable
polypeptide	ENSMUSP00000108923	Ensembl \| MGI Sequence Detail	551	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

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All nucleic 3

cDNA 2

Primer pair 1

Microarray probesets 1

Summaries

All 18

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 5
Earliest

J:157965 Wu W, et al., Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics. 2009 Jul 9;38(2):116-24
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc22a29:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158009	Chr19:8196196-8196213 (-)	59 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24