About   Help   FAQ
Angptl7 Gene Detail
Summary
  • Symbol
    Angptl7
  • Name
    angiopoietin-like 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:3605801
    NCBI Gene: 654812
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148579737-148584919 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 78.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3605801
 protein coding gene Chr4:148579640-148584919 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029125
 protein coding gene Chr4:152217626-152222939 (-)
A/J MGP_AJ_G0029090
 protein coding gene Chr4:145926802-145932597 (-)
AKR/J MGP_AKRJ_G0029038
 protein coding gene Chr4:149899258-149904572 (-)
BALB/cJ MGP_BALBcJ_G0029106
 protein coding gene Chr4:146431718-146437053 (-)
C3H/HeJ MGP_C3HHeJ_G0028827
 protein coding gene Chr4:150461944-150467258 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029555
 protein coding gene Chr4:157756896-157762166 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026801
 protein coding gene Chr4:138345517-138350863 (-)
CAST/EiJ MGP_CASTEiJ_G0028240
 protein coding gene Chr4:147668708-147674064 (-)
CBA/J MGP_CBAJ_G0028789
 protein coding gene Chr4:162325752-162331252 (-)
DBA/2J MGP_DBA2J_G0028938
 protein coding gene Chr4:146031703-146037035 (-)
FVB/NJ MGP_FVBNJ_G0028902
 protein coding gene Chr4:145125458-145130729 (-)
LP/J MGP_LPJ_G0029028
 protein coding gene Chr4:152183514-152188998 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028929
 protein coding gene Chr4:165649688-165655024 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029587
 protein coding gene Chr4:150383702-150389030 (-)
PWK/PhJ MGP_PWKPhJ_G0027960
 protein coding gene Chr4:142021413-142026790 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027794
 protein coding gene Chr4:144644571-144649920 (-)
WSB/EiJ MGP_WSBEiJ_G0028320
 protein coding gene Chr4:150553786-150559082 (-)



Homology
more
  • Human Ortholog
    ANGPTL7, angiopoietin like 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGPTL7, angiopoietin like 7
  • Synonyms
    AngX, CDT6, dJ647M16.1
  • Links
    NCBI Gene ID: 10218
    neXtProt AC: NX_O43827
    UniProt: O43827

  • Chr Location
    1p36.22; chr1:11189355-11195981 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display a non-cell autonomous impairment in hematopoietic stem cell regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    17
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 654812 NCBI Gene Model | MGI Sequence Detail 5183 C57BL/6J ±  kb
transcript NM_001039554 RefSeq | MGI Sequence Detail 2062 C57BL/6  
polypeptide Q8R1Q3 UniProt | EBI | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004032 angiopoietin-related protein 7
    (term hierarchy)
  • InterPro Domains
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR050373 Fibrinogen C-terminal domain-containing protein
    IPR036056 Fibrinogen-like, C-terminal
  • GlyGen
    Q8R1Q3 4 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:350570 Brown SF, et al., ANGPTL7 and Its Role in IOP and Glaucoma. Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):22
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory