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Kdm4d Gene Detail
Summary
  • Symbol
    Kdm4d
  • Name
    lysine (K)-specific demethylase 4D
  • Synonyms
    Jmjd2d
  • Feature Type
    protein coding gene
  • IDs
    MGI:3606484
    NCBI Gene: 244694
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:14373844-14411778 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 4.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    820 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3606484
 protein coding gene Chr9:14373844-14411818 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034349
 protein coding gene Chr9:11394177-11441194 (-)
A/J MGP_AJ_G0034327
 protein coding gene Chr9:11353639-11395849 (-)
AKR/J MGP_AKRJ_G0034255
 protein coding gene Chr9:11357301-11400928 (-)
BALB/cJ MGP_BALBcJ_G0034321
 protein coding gene Chr9:11105228-11149552 (-)
C3H/HeJ MGP_C3HHeJ_G0034032
 protein coding gene Chr9:11653874-11701771 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034843
 protein coding gene Chr9:11767937-11821792 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031781
 protein coding gene Chr9:10654738-10692201 (-)
CAST/EiJ MGP_CASTEiJ_G0033359
 protein coding gene Chr9:11481733-11523043 (-)
CBA/J MGP_CBAJ_G0034005
 protein coding gene Chr9:12310087-12360955 (-)
DBA/2J MGP_DBA2J_G0034162
 protein coding gene Chr9:11238289-11278211 (-)
FVB/NJ MGP_FVBNJ_G0034107
 protein coding gene Chr9:10830931-10863633 (-)
LP/J MGP_LPJ_G0034248
 protein coding gene Chr9:11497348-11534815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034151
 protein coding gene Chr9:13382927-13430410 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034862
 protein coding gene Chr9:11379275-11426688 (-)
PWK/PhJ MGP_PWKPhJ_G0033065
 protein coding gene Chr9:11293605-11332962 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032901
 protein coding gene Chr9:11441176-11485353 (-)
WSB/EiJ MGP_WSBEiJ_G0033475
 protein coding gene Chr9:11216785-11258164 (-)



Homology
more
  • Human Ortholog
    KDM4D, lysine demethylase 4D
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM4D, lysine demethylase 4D
  • Synonyms
    JMJD2D
  • Links
    NCBI Gene ID: 55693
    neXtProt AC: NX_Q6B0I6
    UniProt: Q6B0I6

  • Chr Location
    11q21; chr11:94973709-94999519 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit accumulation of histone 3 methylation in spermatids, a transient increase in testes size, wider tubules, occasional male germ cell apoptosis, and decreased body weight. However, fertility is normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053914 Ensembl Gene Model | MGI Sequence Detail 37935 C57BL/6J ±  kb
    transcript ENSMUST00000058796 Ensembl | MGI Sequence Detail 2695 Not Applicable  
    polypeptide ENSMUSP00000061632 Ensembl | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 10
    • Earliest
      J:6795 Nudel U, et al., Isolation and characterization of rat skeletal muscle and cytoplasmic actin genes. Proc Natl Acad Sci U S A. 1982 May;79(9):2763-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory