Tg(Mt1-Tnfsf4)1Pgn
Transgene Detail

Summary

• Symbol: Tg(Mt1-Tnfsf4)1Pgn
• Name: transgene insertion 1, Beverly Paigen
• MGI ID: MGI:3626317
• Transgene: Tg(Mt1-Tnfsf4)1Pgn Location: unknown
• Alliance: Tg(Mt1-Tnfsf4)1Pgn page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1-Tnfsf4)1Pgn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnfsf4 (MGI:104511)

• Mutation details: The Tnfsf4 cDNA, amplified from mRNA isolated from spleens of C57BL/6J mice, was placed under control of the ubiquitously expressed metallothionein promoter followed by the hemoglobin beta IVS intron. The 3' end of the cDNA, without its polyadenylation signal, was joined to a fragment of the human growth hormone gene, which distinguishes transgene-derived from endogenous transcripts. Transgenic mice express 4- to 250-fold higher levels, depending on tissue type, of transgenic mRNA than do nontransgenic littermates in liver, aorta, heart and spleen. (J:97460)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(Mt1-Tnfsf4)1Pgn/?	C57BL/6J-Tg(Mt1-Tnfsf4)1Pgn

Phenotypes:

Affected Systems	tg1
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cardiovascular system	√
increased susceptibility to atherosclerosis	√
homeostasis/metabolism	N
homeostasis/metabolism phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This line is representative of four transgenic lines. According to the authors, although the line 2 was the primary one described in the reference, all four share the same phenotype.

References

• Original: J:97460 Wang X, et al., Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet. 2005 Apr;37(4):365-72
• All: 1 reference(s)