Slc22a15 MGI Mouse Gene Detail - MGI:3607704 - solute carrier family 22 (organic anion/cation transporter), member 15

Symbol

Slc22a15
Name

solute carrier family 22 (organic anion/cation transporter), member 15
Synonyms

2610034P21Rik, A530052I06Rik

Feature Type

protein coding gene
IDs

MGI:3607704
NCBI Gene: 242126
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:101763092-101831769 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 44.30 cM
Mapping Data

3 experiments

SNPs within 2kb

1931 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3607704	protein coding gene	Chr3:101763084-101831769 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027678	protein coding gene	Chr3:103071576-103134862 (-)
A/J	MGP_AJ_G0027637	protein coding gene	Chr3:99786919-99848719 (-)
AKR/J	MGP_AKRJ_G0027603	protein coding gene	Chr3:102261555-102323448 (-)
BALB/cJ	MGP_BALBcJ_G0027650	protein coding gene	Chr3:99547721-99610389 (-)
C3H/HeJ	MGP_C3HHeJ_G0027379	protein coding gene	Chr3:102547252-102611390 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028093	protein coding gene	Chr3:106874484-106938327 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025434	protein coding gene	Chr3:95979232-96042753 (-)
CAST/EiJ	MGP_CASTEiJ_G0026835	protein coding gene	Chr3:101659284-101724527 (-)
CBA/J	MGP_CBAJ_G0027354	protein coding gene	Chr3:110529049-110599575 (-)
DBA/2J	MGP_DBA2J_G0027497	protein coding gene	Chr3:99035476-99097637 (-)
FVB/NJ	MGP_FVBNJ_G0027465	protein coding gene	Chr3:96971825-97034431 (-)
LP/J	MGP_LPJ_G0027604	protein coding gene	Chr3:104414661-104477992 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027495	protein coding gene	Chr3:116685134-116751525 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028148	protein coding gene	Chr3:101761735-101824836 (-)
PWK/PhJ	MGP_PWKPhJ_G0026562	protein coding gene	Chr3:98793117-98856883 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026384	protein coding gene	Chr3:99836350-99910276 (-)
WSB/EiJ	MGP_WSBEiJ_G0026915	protein coding gene	Chr3:102314108-102378709 (-)

Human Ortholog

SLC22A15, solute carrier family 22 member 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A15, solute carrier family 22 member 15
Synonyms

FLIPT1, PRO34686
Links

HGNC:20301

NCBI Gene ID: 55356

neXtProt AC: NX_Q8IZD6

UniProt: Q8IZD6
Chr Location

1p13.1; chr1:115976513-116070054 (+) GRCh38

MGI Vertebrate Homology

Slc22a15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC22A15
Gene Tree

Slc22a15

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Genomic Mutations

2 involving Slc22a15
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

97
cDNA Data

24
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc22a15, slc22a15.2

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All Sequences

52
RefSeq

2
UniProt

3
CCDS

CCDS51022.1

Ensembl

ENSMUSG00000033147 (Evidence)
NCBI Gene

242126

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033147	Ensembl Gene Model \| MGI Sequence Detail	68678	C57BL/6J	± kb
transcript	ENSMUST00000106928	Ensembl \| MGI Sequence Detail	6573	Not Applicable
polypeptide	ENSMUSP00000102541	Ensembl \| MGI Sequence Detail	544	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014984 solute carrier family 22 member 15

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily
GlyGen

Q504N2 5 sites, 1 N-linked glycan (2 sites)

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All nucleic 26

Genomic 1

cDNA 24

Primer pair 1

Microarray probesets 2

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MGI:1917462, MGI:2140034

Summaries

All 34

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc22a15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34818	Chr3:101831945-101831956 (-)	-182 bp
Tssr34817	Chr3:101831840-101831861 (-)	-82 bp
Tssr34816	Chr3:101831824-101831836 (-)	-61 bp
Tssr34815	Chr3:101831784-101831808 (-)	-27 bp
Tssr34814	Chr3:101831736-101831770 (-)	16 bp
Tssr34813	Chr3:101831694-101831724 (-)	60 bp
Tssr34812	Chr3:101831596-101831615 (-)	163 bp
Tssr34811	Chr3:101831512-101831531 (-)	247 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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