Mslnl MGI Mouse Gene Detail - MGI:3607710

Symbol

Mslnl
Name

mesothelin-like

Feature Type

protein coding gene
IDs

MGI:3607710
NCBI Gene: 328783
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:25955016-25967304 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.84 cM
Mapping Data

1 experiment

SNPs within 2kb

426 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3607710	protein coding gene	Chr17:25952477-25967328 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023363	protein coding gene	Chr17:24829143-24843098 (+)
A/J	MGP_AJ_G0023322	protein coding gene	Chr17:24106594-24120197 (+)
AKR/J	MGP_AKRJ_G0023288	protein coding gene	Chr17:24212153-24224376 (+)
BALB/cJ	MGP_BALBcJ_G0023327	protein coding gene	Chr17:24332494-24346098 (+)
C3H/HeJ	MGP_C3HHeJ_G0023087	protein coding gene	Chr17:24594480-24608873 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023769	protein coding gene	Chr17:25877709-25894340 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021245	protein coding gene	Chr17:21568884-21581438 (+)
CAST/EiJ	MGP_CASTEiJ_G0022589	protein coding gene	Chr17:24474193-24488036 (+)
CBA/J	MGP_CBAJ_G0023062	protein coding gene	Chr17:26787899-26803408 (+)
DBA/2J	MGP_DBA2J_G0023192	protein coding gene	Chr17:23708268-23721314 (+)
FVB/NJ	MGP_FVBNJ_G0023162	protein coding gene	Chr17:23446122-23459615 (+)
LP/J	MGP_LPJ_G0023269	protein coding gene	Chr17:25124207-25138751 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023181	protein coding gene	Chr17:26402698-26416495 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023809	protein coding gene	Chr17:24531980-24544219 (+)
PWK/PhJ	MGP_PWKPhJ_G0022338	protein coding gene	Chr17:22470264-22483033 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022156	protein coding gene	Chr17:22601435-22615399 (+)
WSB/EiJ	MGP_WSBEiJ_G0022652	protein coding gene	Chr17:24582227-24597141 (+)

Human Ortholog

MSLNL, mesothelin like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MSLNL, mesothelin like
Synonyms

C16orf37, MPFL
Links

HGNC:14170

NCBI Gene ID: 401827

UniProt: Q96KJ4
Chr Location

16p13.3

MGI Vertebrate Homology

Mslnl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MSLNL
Gene Tree

Mslnl

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Mslnl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

68 strains or lines available

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All GO Annotations

4
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

Cellular Component

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

6
cDNA Data

3
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

8
UniProt

1
CCDS

CCDS28525.1

Ensembl

ENSMUSG00000041062 (Evidence)
NCBI Gene

328783

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041062	Ensembl Gene Model \| MGI Sequence Detail	12289	C57BL/6J	± kb
transcript	ENSMUST00000047098	Ensembl \| MGI Sequence Detail	2626	Not Applicable
polypeptide	ENSMUSP00000049020	Ensembl \| MGI Sequence Detail	685	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010677 mesothelin-like protein

(term hierarchy)
InterPro Domains

IPR010335 Mesothelin

IPR026664 Stereocilin-related
GlyGen

Q8C160 3 sites, 1 N-linked glycan (1 site)

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 12
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mslnl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5040	Chr17:25955188-25955214 (+)	185 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24