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Elfn2 Gene Detail
Summary
  • Symbol
    Elfn2
  • Name
    leucine rich repeat and fibronectin type III, extracellular 2
  • Synonyms
    Lrrc62
  • Feature Type
    protein coding gene
  • IDs
    MGI:3608416
    NCBI Gene: 207393
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78551531-78602971 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.64 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3608416
 protein coding gene Chr15:78551531-78603056 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022050
 protein coding gene Chr15:78879219-78928745 (-)
A/J MGP_AJ_G0022011
 protein coding gene Chr15:76172248-76220634 (-)
AKR/J MGP_AKRJ_G0021986
 protein coding gene Chr15:78281179-78329960 (-)
BALB/cJ MGP_BALBcJ_G0022017
 protein coding gene Chr15:76144743-76193177 (-)
C3H/HeJ MGP_C3HHeJ_G0021788
 protein coding gene Chr15:78282589-78333409 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022460
 protein coding gene Chr15:81985390-82033310 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019990
 protein coding gene Chr15:72669283-72718101 (-)
CAST/EiJ MGP_CASTEiJ_G0021309
 protein coding gene Chr15:78968655-79017787 (-)
CBA/J MGP_CBAJ_G0021753
 protein coding gene Chr15:84515905-84567109 (-)
DBA/2J MGP_DBA2J_G0021882
 protein coding gene Chr15:75657169-75705784 (-)
FVB/NJ MGP_FVBNJ_G0021860
 protein coding gene Chr15:74661553-74710199 (-)
LP/J MGP_LPJ_G0021950
 protein coding gene Chr15:79091680-79140631 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021880
 protein coding gene Chr15:89697426-89746661 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022474
 protein coding gene Chr15:78308212-78356167 (-)
PWK/PhJ MGP_PWKPhJ_G0021051
 protein coding gene Chr15:75652218-75701531 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020888
 protein coding gene Chr15:78090138-78138386 (-)
WSB/EiJ MGP_WSBEiJ_G0021361
 protein coding gene Chr15:78673330-78722743 (-)



Homology
more
  • Human Ortholog
    ELFN2, extracellular leucine rich repeat and fibronectin type III domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELFN2, extracellular leucine rich repeat and fibronectin type III domain containing 2
  • Synonyms
    LRRC62, PPP1R29
  • Links
    NCBI Gene ID: 114794
    neXtProt AC: NX_Q5R3F8
    UniProt: Q5R3F8

  • Chr Location
    22q13.1; chr22:37339583-37427479 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show loss of glutamatergic autoreceptors, augmented excitatory synaptic transmission, hyperactivity, anxiety- and compulsivity-like behaviors, impaired sociability, and increased susceptibility to audiogenic and pharmacologically-induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    16
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043460 Ensembl Gene Model | MGI Sequence Detail 51441 C57BL/6J ±  kb
    transcript ENSMUST00000229441 Ensembl | MGI Sequence Detail 7537 Not Applicable  
    polypeptide ENSMUSP00000155111 Ensembl | MGI Sequence Detail 823 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031181 protein phosphatase 1 regulatory subunit 29
      (term hierarchy)
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR050541 Leucine-rich repeat and transmembrane domain-containing protein
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      Q68FM6 8 sites, 11 N-linked glycans (6 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146181
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 4
      Phenotypes 30
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory