Nlrc5 MGI Mouse Gene Detail - MGI:3612191 - NLR family, CARD domain containing 5

Symbol

Nlrc5
Name

NLR family, CARD domain containing 5
Synonyms

AI451557

Feature Type

protein coding gene
IDs

MGI:3612191
NCBI Gene: 434341
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr8:95160984-95253900 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 46.55 cM
Mapping Data

2 experiments

SNPs within 2kb

1961 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3612191	protein coding gene	Chr8:95160963-95253900 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033961	protein coding gene	Chr8:95853546-95955295 (+)
A/J	MGP_AJ_G0033944	protein coding gene	Chr8:92150753-92214341 (+)
AKR/J	MGP_AKRJ_G0033870	protein coding gene	Chr8:94677249-94731032 (+)
BALB/cJ	MGP_BALBcJ_G0033936	protein coding gene	Chr8:92249788-92305101 (+)
C3H/HeJ	MGP_C3HHeJ_G0033646	protein coding gene	Chr8:95391984-95447043 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034457	protein coding gene	Chr8:99392722-99451285 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031398	protein coding gene	Chr8:85942984-86017358 (+)
CAST/EiJ	MGP_CASTEiJ_G0032978	protein coding gene	Chr8:94944467-95031061 (+)
CBA/J	MGP_CBAJ_G0033622	protein coding gene	Chr8:102690249-102752514 (+)
DBA/2J	MGP_DBA2J_G0033776	protein coding gene	Chr8:91628004-91683010 (+)
FVB/NJ	MGP_FVBNJ_G0033723	protein coding gene	Chr8:90594936-90649455 (+)
LP/J	MGP_LPJ_G0033868	protein coding gene	Chr8:96037926-96097705 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033765	protein coding gene	Chr8:104949995-105045314 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034475	protein coding gene	Chr8:94801420-94901678 (+)
PWK/PhJ	MGP_PWKPhJ_G0032680	protein coding gene	Chr8:90967329-91055496 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032517	protein coding gene	Chr8:93658175-93722596 (+)
WSB/EiJ	MGP_WSBEiJ_G0033090	protein coding gene	Chr8:95333540-95427887 (+)

Human Ortholog

NLRC5, NLR family CARD domain containing 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NLRC5, NLR family CARD domain containing 5
Synonyms

CLR16.1, NOD27, NOD4
Links

HGNC:29933

NCBI Gene ID: 84166

neXtProt AC: NX_Q86WI3

UniProt: Q86WI3
Chr Location

16q13; chr16:56989485-57083531 (+) GRCh38

MGI Vertebrate Homology

Nlrc5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NLRC5
Gene Tree

Nlrc5

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Phenotype Summary

6 phenotypes from 3 alleles in 3 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Endonuclease-mediated

3
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal cytokine production induced by virus and bacteria infection.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
cDNA Data

42
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nlrc5

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All Sequences

55
RefSeq

12
UniProt

4
CCDS

CCDS59741.1

Ensembl

ENSMUSG00000074151 (Evidence)
NCBI Gene

434341

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074151	Ensembl Gene Model \| MGI Sequence Detail	92917	C57BL/6J	± kb
transcript	ENSMUST00000211816	Ensembl \| MGI Sequence Detail	7578	Not Applicable
polypeptide	ENSMUSP00000148677	Ensembl \| MGI Sequence Detail	1915	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011263 protein NLRC5

(term hierarchy)
PDB

2MJM
InterPro Domains

IPR001611 Leucine-rich repeat

IPR006553 Leucine-rich repeat, cysteine-containing subtype

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2

IPR007111 NACHT nucleoside triphosphatase

IPR041210 NLRC5, atypical caspase recruitment domain

IPR051261 NOD-like receptor (NLR)

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 43

cDNA 42

Primer pair 1

Microarray probesets 4

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MGI:2142553

Summaries

All 60

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 23
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:343973 Bauer S, et al., NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARgamma target genes. iScience. 2023 Apr 21;26(4):106313

TSS for Nlrc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78863	Chr8:95160971-95160982 (+)	-7 bp
Tssr78864	Chr8:95161006-95161031 (+)	35 bp
Tssr78865	Chr8:95161351-95161372 (+)	378 bp
Tssr78866	Chr8:95172960-95172962 (+)	11,977 bp
Tssr78867	Chr8:95176295-95176300 (+)	15,314 bp
Tssr78868	Chr8:95176397-95176424 (+)	15,427 bp
Tssr78869	Chr8:95176830-95176841 (+)	15,852 bp
Tssr78870	Chr8:95187099-95187103 (+)	26,117 bp
Tssr78871	Chr8:95187153-95187162 (+)	26,174 bp
Tssr78872	Chr8:95187404-95187407 (+)	26,422 bp
Tssr78873	Chr8:95205272-95205289 (+)	44,297 bp
Tssr78874	Chr8:95205322-95205350 (+)	44,352 bp
Tssr78875	Chr8:95206504-95206535 (+)	45,536 bp
Tssr78876	Chr8:95207212-95207225 (+)	46,235 bp
Tssr78877	Chr8:95207309-95207320 (+)	46,331 bp
Tssr78878	Chr8:95207326-95207340 (+)	46,349 bp
Tssr78879	Chr8:95239933-95239950 (+)	78,958 bp
Tssr78880	Chr8:95239958-95239969 (+)	78,980 bp
Tssr2652	Chr8:95251472-95251482 (+)	90,493 bp
Tssr78881	Chr8:95251500-95251510 (+)	90,521 bp
Tssr78882	Chr8:95253442-95253446 (+)	92,460 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24