Ascla5 QTL Detail

Summary

• Symbol
  Ascla5
• Name
  atherosclerotic lesion area 5

• Feature Type
  QTL
• IDs
  MGI:3613544
  NCBI Gene: 100035273
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 12, 7.03 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  100035273

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:104621 Teupser D, et al., Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):123-8
• Latest
  J:149028 Holdt LM, et al., Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient mice. Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1097-103

Candidate Genes for Ascla5:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Adam17	Chr12:21373510-21423633 (-)	J:149028	Refined QTL mapping using a subset of F2 mice from the C57BL/6J-Ldlr X FVB/N-Ldlr cross (J:104621) was informative in mapping a Adam17 exon 19 SNP significantly to a the region identified as Ascla5(J:104621). The LOD score associated with the exon 19 SNP was 4.2.