Ripply1 MGI Mouse Gene Detail - MGI:3614797 - ripply transcriptional repressor 1

Symbol

Ripply1
Name

ripply transcriptional repressor 1

Feature Type

protein coding gene
IDs

MGI:3614797
NCBI Gene: 622473
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

ChrX:138680430-138683102 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 61.35 cM
Mapping Data

1 experiment

SNPs within 2kb

114 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3614797	protein coding gene	ChrX:138680298-138683102 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036127	protein coding gene	ChrX:137293274-137296078 (-)
A/J	MGP_AJ_G0036105	protein coding gene	ChrX:136669237-136672323 (-)
AKR/J	MGP_AKRJ_G0036030	protein coding gene	ChrX:141065683-141068475 (-)
BALB/cJ	MGP_BALBcJ_G0036095	protein coding gene	ChrX:135020800-135023598 (-)
C3H/HeJ	MGP_C3HHeJ_G0035804	protein coding gene	ChrX:137327592-137330396 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036620	protein coding gene	ChrX:141329189-141331993 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033444	protein coding gene	ChrX:128428137-128430871 (-)
CAST/EiJ	MGP_CASTEiJ_G0035095	protein coding gene	ChrX:118127764-118130561 (-)
CBA/J	MGP_CBAJ_G0035781	protein coding gene	ChrX:145654388-145657166 (-)
DBA/2J	MGP_DBA2J_G0035938	protein coding gene	ChrX:135847807-135850599 (-)
FVB/NJ	MGP_FVBNJ_G0035872	protein coding gene	ChrX:135080835-135083649 (-)
LP/J	MGP_LPJ_G0036029	protein coding gene	ChrX:138265240-138268187 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035909	protein coding gene	ChrX:153178426-153181212 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036656	protein coding gene	ChrX:136604924-136607716 (-)
PWK/PhJ	MGP_PWKPhJ_G0034788	protein coding gene	ChrX:115051235-115054013 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034614	protein coding gene	ChrX:118662579-118665333 (-)
WSB/EiJ	MGP_WSBEiJ_G0035230	protein coding gene	ChrX:134931088-134934193 (-)

Human Ortholog

RIPPLY1, ripply transcriptional repressor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIPPLY1, ripply transcriptional repressor 1
Links

HGNC:25117

NCBI Gene ID: 92129

neXtProt AC: NX_Q0D2K3

UniProt: Q0D2K3
Chr Location

Xq22.3; chrX:106900063-106903341 (-) GRCh38

MGI Vertebrate Homology

Ripply1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RIPPLY1
Gene Tree

Ripply1

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

4
Targeted

4
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit extension of the seventh cervical vertebrae that fuses with the first rib. However, mice are otherwise viable.

less

All GO Annotations

13
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

8
cDNA Data

1
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ripply1

less

All Sequences

26
RefSeq

2
UniProt

1
CCDS

CCDS30436.1

Ensembl

ENSMUSG00000072945 (Evidence)
NCBI Gene

622473

			Length	Strain/Species	Flank
genomic	622473	NCBI Gene Model \| MGI Sequence Detail	2673	C57BL/6J	± kb
transcript	NM_001037915	RefSeq \| MGI Sequence Detail	679	Not Specified
polypeptide	Q2WG77	UniProt \| EBI \| MGI Sequence Detail	201	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000014026 protein ripply1

(term hierarchy)
InterPro Domains

IPR028127 Ripply family

less

All nucleic 3

cDNA 2

Primer pair 1

Microarray probesets 1

Summaries

All 20

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 6
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ripply1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5686	ChrX:138683244-138683245 (-)	-143 bp
Tssr164219	ChrX:138683108-138683117 (-)	-11 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24