Del(11Irf1-D11Mit23)1Rub Cytogenetic Marker Detail

Summary

• Symbol
  Del(11Irf1-D11Mit23)1Rub
• Name
  deletion, Chr 11, Edward M Rubin 1
• Synonyms
  del¹¹, Del(11Irf1-Csf2)1Rub, Del1Rub

• Feature Type
  chromosomal deletion
• IDs
  MGI:3614963

Location &
Maps

• Sequence Map
  Chr11:53660841-54126873 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  16 phenotypes from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  1 strains or lines available

Deletion homozygotes exhibit growth retardation, enlargement of the heart and liver, severe hypertriglyceridemia due to several-fold elevated hepatic secretion of very low density lipoprotein (VLDL) triglycerides, and premature death.

References

• Summaries
  All 2

  Phenotypes 1
• Earliest
  J:60187 Zhu Y, et al., Genomic interval engineering of mice identifies a novel modulator of triglyceride production. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1137-42