Tg(Tyr-cre/ERT2)1Lru
Transgene Detail

Summary

• Symbol: Tg(Tyr-cre/ERT2)1Lru
• Name: transgene insertion 1, Lionel Larue
• MGI ID: MGI:3617509
• Synonyms: Tg(Tyr-cre/ERT2)1Laru, Tyr::Cre-ERT2, Tyr::CreER^T2-Lar
• Transgene: Tg(Tyr-cre/ERT2)1Lru Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Tg(Tyr-cre/ERT2)1Lru page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Duplication, Insertion, Intergenic deletion
• Tg(Tyr-cre/ERT2)1Lru involves 10 genes/genome features (Fam171a1, Nmt2, Rpp38 ...) View all
• Tg(Tyr-cre/ERT2)1Lru expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Tyr

• Mutation details: This transgene expresses a tamoxifen-inducible form of cre recombinase under the control of the tyrosinase enhancer and promoter, active in melanoblasts and melanocytes. The transgene inserted on the proximal end of chromosome 7 fused to a ~3 million base pair duplication from the proximal end of chromosome 2. This insertion also caused the deletion of some chromosome 7 loci. Specifically, the insertion occurred on chromosome 7 into exon 10 of the Nlrp12 locus (3,220,560; mouse mm10), causing deletion of centromeric sequences including the entire Speer9-ps1 and Au018091 loci as well as the remaining 3' Nlrp12 sequences. The duplicated chromosome 2 sequences (now fused to the transgene on chromosome 7) include the entire Fam171a1, Nmt2, Rpp38, Olah1, Meig1, and Dclre1c loci, as well as a portion of Suv39h2 lacking exons 1-2. Therefore, animals hemizygous for the Tg(Tyr-cre/ERT2)1Lru allele carries three copies of the duplicated chromosome 2 genes, but only one functional copy of the deleted chromosome 7 genes. (J:105276, J:282623)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tyr (species not specified) Summary of all recombinase alleles driven by Tyr. Comparative matrix view of recombinase activities

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:105276 Yajima I, et al., Spatiotemporal gene control by the Cre-ERT2 system in melanocytes. Genesis. 2006 Jan;44(1):34-43
• All: 32 reference(s)