Mir196a-2 MGI Mouse Gene Detail - MGI:3618739

Symbol

Mir196a-2
Name

microRNA 196a-2
Synonyms

mir 196a-2, Mirn196a-2, mmu-mir-196a-2

Feature Type

miRNA gene
IDs

MGI:3618739
NCBI Gene: 723958
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:102881785-102881869 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 58.04 cM
Mapping Data

1 experiment

SNPs within 2kb

29 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3618739	miRNA gene	Chr15:102881785-102881869 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0008233	miRNA gene	Chr15:105208880-105208964 (+)
A/J	MGP_AJ_G0008223	miRNA gene	Chr15:101051991-101052075 (+)
AKR/J	MGP_AKRJ_G0008206	miRNA gene	Chr15:104121274-104121358 (+)
BALB/cJ	MGP_BALBcJ_G0008208	miRNA gene	Chr15:101100023-101100107 (+)
C3H/HeJ	MGP_C3HHeJ_G0008150	miRNA gene	Chr15:104197929-104198013 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008400	miRNA gene	Chr15:109104544-109104628 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007468	miRNA gene	Chr15:96821669-96821753 (+)
CAST/EiJ	MGP_CASTEiJ_G0008019	miRNA gene	Chr15:105071242-105071326 (+)
CBA/J	MGP_CBAJ_G0008119	miRNA gene	Chr15:112937400-112937484 (+)
DBA/2J	MGP_DBA2J_G0008152	miRNA gene	Chr15:100322359-100322443 (+)
FVB/NJ	MGP_FVBNJ_G0008176	miRNA gene	Chr15:99391959-99392043 (+)
LP/J	MGP_LPJ_G0008233	miRNA gene	Chr15:105344032-105344116 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0008139	miRNA gene	Chr15:116452723-116452807 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008392	miRNA gene	Chr15:104160129-104160213 (+)
PWK/PhJ	MGP_PWKPhJ_G0007941	miRNA gene	Chr15:100501816-100501900 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007832	miRNA gene	Chr15:103989936-103990020 (+)
WSB/EiJ	MGP_WSBEiJ_G0008097	miRNA gene	Chr15:104774808-104774892 (+)

Human Ortholog

MIR196A2, microRNA 196a-2

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR196A2, microRNA 196a-2
Synonyms

mir-196a-2, MIRN196-2, MIRN196A2
Links

HGNC:31568

NCBI Gene ID: 406973
Chr Location

chr12:53991738-53991847 (+) GRCh38

MGI Vertebrate Homology

Mir196a-2 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR196A2
Gene Tree

Mir196a-2

Diseases

1 with human MIR196A2 associations

				Human Disease	Mouse Models
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Mir196a-2
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out alele exhibit anterior homeotic transformation with rudimentary rib on the first lumbar vertebrae or anterior homeotic transformation of all sacral elements with posterior displacement of the sacrum.

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

24
RefSeq

1

Ensembl

ENSMUSG00000065488 (Evidence)
NCBI Gene

723958

Representative Sequences				Length	Strain/Species	Flank
	genomic	723958	NCBI Gene Model \| MGI Sequence Detail	85	C57BL/6J	± kb
	transcript	NR_029722	RefSeq \| MGI Sequence Detail	85	C57BL/6

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All nucleic 3

Other 3

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miRBase

MI0000553

Summaries

All 48

Developmental Gene Expression 10

Diseases 1

Gene Ontology 5

Phenotypes 29
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:317804 Hauswirth GM, et al., Breaking constraint of mammalian axial formulae. Nat Commun. 2022 Jan 11;13(1):243

TSS for Mir196a-2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133481	Chr15:102879871-102879909 (+)	-1,895 bp
Tssr133482	Chr15:102880664-102880670 (+)	-1,118 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24