Mir221 MGI Mouse Gene Detail - MGI:3619066

Symbol

Mir221
Name

microRNA 221
Synonyms

mir 221, Mirn221, mmu-mir-221

Feature Type

miRNA gene
IDs

MGI:3619066
NCBI Gene: 723827
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

ChrX:19012533-19012627 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 14.52 cM
Mapping Data

1 experiment

SNPs within 2kb

78 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3619066	miRNA gene	ChrX:19012533-19012627 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0009262	miRNA gene	ChrX:14016705-14016799 (-)
A/J	MGP_AJ_G0009242	miRNA gene	ChrX:14165219-14165313 (-)
AKR/J	MGP_AKRJ_G0009232	miRNA gene	ChrX:14555576-14555670 (-)
BALB/cJ	MGP_BALBcJ_G0009226	miRNA gene	ChrX:13844060-13844154 (-)
C3H/HeJ	MGP_C3HHeJ_G0009166	miRNA gene	ChrX:14200089-14200183 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0009469	miRNA gene	ChrX:14369682-14369776 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0008316	miRNA gene	ChrX:12482161-12482255 (-)
CAST/EiJ	MGP_CASTEiJ_G0008995	miRNA gene	ChrX:13636818-13636912 (-)
CBA/J	MGP_CBAJ_G0009133	miRNA gene	ChrX:15041735-15041829 (-)
DBA/2J	MGP_DBA2J_G0009163	miRNA gene	ChrX:13916204-13916298 (-)
FVB/NJ	MGP_FVBNJ_G0009180	miRNA gene	ChrX:13846249-13846343 (-)
LP/J	MGP_LPJ_G0009260	miRNA gene	ChrX:14289420-14289514 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0009147	miRNA gene	ChrX:15249098-15249192 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0009439	miRNA gene	ChrX:13945684-13945778 (-)
PWK/PhJ	MGP_PWKPhJ_G0008921	miRNA gene	ChrX:13175564-13175658 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0008758	miRNA gene	ChrX:13926055-13926149 (-)
WSB/EiJ	MGP_WSBEiJ_G0009091	miRNA gene	ChrX:13857781-13857875 (-)

Human Ortholog

MIR221, microRNA 221

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR221, microRNA 221
Synonyms

mir-221, MIRN221, miRNA221
Links

HGNC:31601

NCBI Gene ID: 407006
Chr Location

chrX:45746157-45746266 (-) GRCh38

MGI Vertebrate Homology

Mir221 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR221
Gene Tree

Mir221

Diseases

3 with human MIR221 associations

				Human Disease	Mouse Models
				gastrointestinal stromal tumor IDs gastrointestinal stromal tumor DOID:9253 ICD10CM:C49.A MESH:D046152 NCI:C3868 OMIM:606764 UMLS_CUI:C0238198
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				oral squamous cell carcinoma IDs oral squamous cell carcinoma DOID:0050866

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype reference

All Mutations and Alleles

2
Endonuclease-mediated

2
Find Mice (IMSR)

3 strains or lines available

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All GO Annotations

11
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

22
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000065422 (Evidence)
NCBI Gene

723827

Representative Sequences				Length	Strain/Species	Flank
	genomic	723827	NCBI Gene Model \| MGI Sequence Detail	95	C57BL/6J	± kb
	transcript	NR_029806	RefSeq \| MGI Sequence Detail	95	C57BL/6

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All nucleic 5

Primer pair 3

Other 2

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miRBase

MI0000709

Summaries

All 49

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 1
Earliest

J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
Latest

J:354582 Roumelioti F, et al., Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components. Elife. 2024 Sep 5;13

TSS for Mir221:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163041	ChrX:19012537-19012551 (-)	83 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24