About   Help   FAQ
Mir221 Gene Detail
Summary
  • Symbol
    Mir221
  • Name
    microRNA 221
  • Synonyms
    mir 221, Mirn221, mmu-mir-221
  • Feature Type
    miRNA gene
  • IDs
    MGI:3619066
    NCBI Gene: 723827
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:19012533-19012627 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 14.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619066
 miRNA gene ChrX:19012533-19012627 (-)
129S1/SvImJ MGP_129S1SvImJ_G0009262
 miRNA gene ChrX:14016705-14016799 (-)
A/J MGP_AJ_G0009242
 miRNA gene ChrX:14165219-14165313 (-)
AKR/J MGP_AKRJ_G0009232
 miRNA gene ChrX:14555576-14555670 (-)
BALB/cJ MGP_BALBcJ_G0009226
 miRNA gene ChrX:13844060-13844154 (-)
C3H/HeJ MGP_C3HHeJ_G0009166
 miRNA gene ChrX:14200089-14200183 (-)
C57BL/6NJ MGP_C57BL6NJ_G0009469
 miRNA gene ChrX:14369682-14369776 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0008316
 miRNA gene ChrX:12482161-12482255 (-)
CAST/EiJ MGP_CASTEiJ_G0008995
 miRNA gene ChrX:13636818-13636912 (-)
CBA/J MGP_CBAJ_G0009133
 miRNA gene ChrX:15041735-15041829 (-)
DBA/2J MGP_DBA2J_G0009163
 miRNA gene ChrX:13916204-13916298 (-)
FVB/NJ MGP_FVBNJ_G0009180
 miRNA gene ChrX:13846249-13846343 (-)
LP/J MGP_LPJ_G0009260
 miRNA gene ChrX:14289420-14289514 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0009147
 miRNA gene ChrX:15249098-15249192 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0009439
 miRNA gene ChrX:13945684-13945778 (-)
PWK/PhJ MGP_PWKPhJ_G0008921
 miRNA gene ChrX:13175564-13175658 (-)
SPRET/EiJ MGP_SPRETEiJ_G0008758
 miRNA gene ChrX:13926055-13926149 (-)
WSB/EiJ MGP_WSBEiJ_G0009091
 miRNA gene ChrX:13857781-13857875 (-)



Homology
more
  • Human Ortholog
    MIR221, microRNA 221
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR221, microRNA 221
  • Synonyms
    mir-221, MIRN221, miRNA221
  • Links
    NCBI Gene ID: 407006

  • Chr Location
    chrX:45746157-45746266 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human MIR221 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    22
  • Literature Summary
    6
Sequences &
Gene Models
less
  • All Sequences
    23
  • RefSeq
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 723827 NCBI Gene Model | MGI Sequence Detail 95 C57BL/6J ±  kb
transcript NR_029806 RefSeq | MGI Sequence Detail 95 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 5
    Primer pair 3
    Other 2
Other Database
Links
less
miRBase MI0000709
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 1
  • Earliest
    J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
  • Latest
    J:354582 Roumelioti F, et al., Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components. Elife. 2024 Sep 5;13
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory