Mir33 MGI Mouse Gene Detail - MGI:3619343

Symbol

Mir33
Name

microRNA 33
Synonyms

mir 33, Mirn33, mmu-mir-33

Feature Type

miRNA gene
IDs

MGI:3619343
NCBI Gene: 723897
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:82082323-82082391 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.54 cM
Mapping Data

1 experiment

SNPs within 2kb

101 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3619343	miRNA gene	Chr15:82082323-82082391 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0008200	miRNA gene	Chr15:82694081-82694149 (+)
A/J	MGP_AJ_G0008190	miRNA gene	Chr15:79765353-79765421 (+)
AKR/J	MGP_AKRJ_G0008171	miRNA gene	Chr15:81974188-81974256 (+)
BALB/cJ	MGP_BALBcJ_G0008173	miRNA gene	Chr15:79815397-79815465 (+)
C3H/HeJ	MGP_C3HHeJ_G0008115	miRNA gene	Chr15:81992724-81992792 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008366	miRNA gene	Chr15:85930454-85930522 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007444	miRNA gene	Chr15:76206121-76206189 (+)
CAST/EiJ	MGP_CASTEiJ_G0007990	miRNA gene	Chr15:82789567-82789635 (+)
CBA/J	MGP_CBAJ_G0008084	miRNA gene	Chr15:88618280-88618348 (+)
DBA/2J	MGP_DBA2J_G0008119	miRNA gene	Chr15:79238743-79238811 (+)
FVB/NJ	MGP_FVBNJ_G0008144	miRNA gene	Chr15:78298609-78298677 (+)
LP/J	MGP_LPJ_G0008199	miRNA gene	Chr15:82837165-82837233 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0008109	miRNA gene	Chr15:93528877-93528945 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008360	miRNA gene	Chr15:82087817-82087885 (+)
PWK/PhJ	MGP_PWKPhJ_G0007913	miRNA gene	Chr15:79291667-79291735 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007803	miRNA gene	Chr15:81868188-81868256 (+)
WSB/EiJ	MGP_WSBEiJ_G0008069	miRNA gene	Chr15:82502339-82502407 (+)

Human Ortholog

MIR33A, microRNA 33a

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR33A, microRNA 33a
Synonyms

hsa-mir-33, hsa-mir-33a, miR-33, MIR33, mir-33a, MIRN33, MIRN33A, miRNA33A
Links

HGNC:31634

NCBI Gene ID: 407039
Chr Location

chr22:41900944-41901012 (+) GRCh38

MGI Vertebrate Homology

Mir33 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR33A
Gene Tree

Mir33

less

References

1 with disease annotations

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Mir33
Find Mice (IMSR)

1 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display increased cellular cholesterol efflux and elevated circulating total and HDL cholesterol levels.

less

All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

less

All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000065465 (Evidence)
NCBI Gene

723897

Representative Sequences				Length	Strain/Species	Flank
	genomic	723897	NCBI Gene Model \| MGI Sequence Detail	69	C57BL/6J	± kb
	transcript	NR_029804	RefSeq \| MGI Sequence Detail	69	C57BL/6

less

All nucleic 1

Other 1

less

miRBase

MI0000707

Summaries

All 66

Developmental Gene Expression 3

Diseases 1

Gene Ontology 1

Phenotypes 31
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:342807 Ahangari F, et al., microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight. 2023 Feb 22;8(4)

TSS for Mir33:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4665	Chr15:82081615-82081618 (+)	-706 bp
Tssr132361	Chr15:82081720-82081731 (+)	-597 bp
Tssr4666	Chr15:82081801-82081812 (+)	-516 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24