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Mir34a Gene Detail
Summary
  • Symbol
    Mir34a
  • Name
    microRNA 34a
  • Synonyms
    mir 34a, Mirn34a, mmu-mir-34a
  • Feature Type
    miRNA gene
  • IDs
    MGI:3619363
    NCBI Gene: 723848
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:150152911-150153012 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 80.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619363
 miRNA gene Chr4:150152911-150153012 (+)
129S1/SvImJ MGP_129S1SvImJ_G0008788
 miRNA gene Chr4:153994595-153994696 (+)
A/J MGP_AJ_G0008771
 miRNA gene Chr4:147545773-147545874 (+)
AKR/J MGP_AKRJ_G0008763
 miRNA gene Chr4:151601202-151601303 (+)
BALB/cJ MGP_BALBcJ_G0008761
 miRNA gene Chr4:148044693-148044794 (+)
C3H/HeJ MGP_C3HHeJ_G0008701
 miRNA gene Chr4:152132527-152132628 (+)
C57BL/6NJ MGP_C57BL6NJ_G0008983
 miRNA gene Chr4:159540556-159540657 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0007923
 miRNA gene Chr4:139954297-139954398 (+)
CAST/EiJ MGP_CASTEiJ_G0008542
 miRNA gene Chr4:149380845-149380946 (+)
CBA/J MGP_CBAJ_G0008667
 miRNA gene Chr4:164233743-164233844 (+)
DBA/2J MGP_DBA2J_G0008697
 miRNA gene Chr4:147639825-147639926 (+)
FVB/NJ MGP_FVBNJ_G0008717
 miRNA gene Chr4:146767221-146767322 (+)
LP/J MGP_LPJ_G0008793
 miRNA gene Chr4:153922075-153922176 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0008683
 miRNA gene Chr4:167405198-167405299 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0008964
 miRNA gene Chr4:152093531-152093632 (+)
PWK/PhJ MGP_PWKPhJ_G0008472
 miRNA gene Chr4:143655774-143655875 (+)
SPRET/EiJ MGP_SPRETEiJ_G0008324
 miRNA gene Chr4:146353946-146354047 (+)
WSB/EiJ MGP_WSBEiJ_G0008639
 miRNA gene Chr4:152233345-152233446 (+)



Homology
more
  • Human Ortholog
    MIR34A, microRNA 34a
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR34A, microRNA 34a
  • Synonyms
    mir-34, mir-34a, MIRN34A, miRNA34A
  • Links
    NCBI Gene ID: 407040

  • Chr Location
    chr1:9151668-9151777 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MIR34A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 5 alleles in 5 genetic backgrounds
    35 phenotypes from multigenic genotypes
    1 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal neuroprogenitor cell proliferation in the subventricular zone or increased reprogramming efficiency of mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    23
  • Literature Summary
    15
Sequences &
Gene Models
less
  • All Sequences
    23
  • RefSeq
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 723848 NCBI Gene Model | MGI Sequence Detail 102 C57BL/6J ±  kb
transcript NR_029751 RefSeq | MGI Sequence Detail 102 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 10
    Primer pair 7
    Other 3
Other Database
Links
less
miRBase MI0000584
References
more
  • Summaries
    All 128
    Developmental Gene Expression 15
    Gene Ontology 7
    Phenotypes 44
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:338755 Wan Y, et al., Liver-specific deletion of microRNA-34a alleviates ductular reaction and liver fibrosis during experimental cholestasis. FASEB J. 2023 Feb;37(2):e22731
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory