Mir379 MGI Mouse Gene Detail - MGI:3619386

Symbol

Mir379
Name

microRNA 379
Synonyms

mir 379, Mirn379, mmu-mir-379

Feature Type

miRNA gene
IDs

MGI:3619386
NCBI Gene: 723858
Member of

Mirc6 cluster, Mirc36 cluster
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:109675494-109675559 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 60.56 cM
Mapping Data

1 experiment

SNPs within 2kb

49 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3619386	miRNA gene	Chr12:109675494-109675559 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0007979	miRNA gene	Chr12:111952712-111952777 (+)
A/J	MGP_AJ_G0007973	miRNA gene	Chr12:107634934-107634999 (+)
AKR/J	MGP_AKRJ_G0007950	miRNA gene	Chr12:110772455-110772520 (+)
BALB/cJ	MGP_BALBcJ_G0007952	miRNA gene	Chr12:108105750-108105815 (+)
C3H/HeJ	MGP_C3HHeJ_G0007898	miRNA gene	Chr12:111215622-111215687 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008133	miRNA gene	Chr12:115363111-115363176 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007260	miRNA gene	Chr12:104154962-104155027 (+)
CAST/EiJ	MGP_CASTEiJ_G0007786	miRNA gene	Chr12:106175321-106175386 (+)
CBA/J	MGP_CBAJ_G0007868	miRNA gene	Chr12:119898337-119898402 (+)
DBA/2J	MGP_DBA2J_G0007903	miRNA gene	Chr12:107189593-107189658 (+)
FVB/NJ	MGP_FVBNJ_G0007922	miRNA gene	Chr12:105983028-105983093 (+)
LP/J	MGP_LPJ_G0007984	miRNA gene	Chr12:111775630-111775695 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0007893	miRNA gene	Chr12:123060123-123060188 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008128	miRNA gene	Chr12:110255816-110255881 (+)
PWK/PhJ	MGP_PWKPhJ_G0007708	miRNA gene	Chr12:101800038-101800103 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007605	miRNA gene	Chr12:104420438-104420503 (+)
WSB/EiJ	MGP_WSBEiJ_G0007855	miRNA gene	Chr12:111171382-111171447 (+)

Human Ortholog

MIR379, microRNA 379

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR379, microRNA 379
Synonyms

hsa-mir-379, mir-379, MIRN379
Links

HGNC:31872

NCBI Gene ID: 494328
Chr Location

chr14:101022066-101022132 (+) GRCh38

MGI Vertebrate Homology

Mir379 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR379
Gene Tree

Mir379

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Targeted

7
Genomic Mutations

4 involving Mir379
Find Mice (IMSR)

3 strains or lines available

While males show normal incidence of streptozotocin-induced insulin-dependent diabetes, they are protected from key features of diabetic kidney disease, including renal dysfunction, glomerular expansion, renal fibrosis, and glomerular basement membrane thickening compared to diabetic wild-type mice.

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All GO Annotations

8
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000065498 (Evidence)
NCBI Gene

723858

Representative Sequences				Length	Strain/Species	Flank
	genomic	723858	NCBI Gene Model \| MGI Sequence Detail	66	C57BL/6J	± kb
	transcript	NR_029880	RefSeq \| MGI Sequence Detail	66	C57BL/6

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All nucleic 2

Primer pair 1

Other 1

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miRBase

MI0000796

Summaries

All 31

Developmental Gene Expression 8

Gene Ontology 7

Phenotypes 11
Earliest

J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
Latest

J:344878 Abdollahi M, et al., Role of miR-379 in high-fat diet-induced kidney injury and dysfunction. Am J Physiol Renal Physiol. 2022 Dec 1;323(6):F686-F699

TSS for Mir379:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115174	Chr12:109675557-109675560 (+)	65 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24