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Mir449a Gene Detail
Summary
  • Symbol
    Mir449a
  • Name
    microRNA 449a
  • Synonyms
    mir 449, Mirn449a, mmu-mir-449a
  • Feature Type
    miRNA gene
  • IDs
    MGI:3619407
    NCBI Gene: 723868
  • Member of
    Mirc34 cluster
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:113174068-113174158 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 63.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619407
miRNA gene Chr13:113174068-113174158 (+)
129S1/SvImJ MGP_129S1SvImJ_G0008100
miRNA gene Chr13:115644659-115644749 (+)
A/J MGP_AJ_G0008088
miRNA gene Chr13:111018166-111018256 (+)
AKR/J MGP_AKRJ_G0008068
miRNA gene Chr13:114368252-114368342 (+)
BALB/cJ MGP_BALBcJ_G0008070
miRNA gene Chr13:111713760-111713850 (+)
C3H/HeJ MGP_C3HHeJ_G0008014
miRNA gene Chr13:114160848-114160938 (+)
C57BL/6NJ MGP_C57BL6NJ_G0008257
miRNA gene Chr13:119065995-119066085 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0007354
miRNA gene Chr13:106308474-106308564 (+)
CAST/EiJ MGP_CASTEiJ_G0007894
miRNA gene Chr13:113800167-113800257 (+)
CBA/J MGP_CBAJ_G0007982
miRNA gene Chr13:123672491-123672581 (+)
DBA/2J MGP_DBA2J_G0008017
miRNA gene Chr13:110729620-110729710 (+)
FVB/NJ MGP_FVBNJ_G0008041
miRNA gene Chr13:109430924-109431014 (+)
LP/J MGP_LPJ_G0008100
miRNA gene Chr13:115678306-115678396 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0008009
miRNA gene Chr13:123926712-123926802 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0008255
miRNA gene Chr13:113833792-113833882 (+)
PWK/PhJ MGP_PWKPhJ_G0007814
miRNA gene Chr13:109479905-109479995 (+)
SPRET/EiJ MGP_SPRETEiJ_G0007711
miRNA gene Chr13:110147889-110147979 (+)
WSB/EiJ MGP_WSBEiJ_G0007968
miRNA gene Chr13:114430421-114430511 (+)



Homology
more
  • Human Ortholog
    MIR449A, microRNA 449a
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR449A, microRNA 449a
  • Synonyms
    hsa-mir-449, mir-449a, MIRN449, MIRN449A
  • Links
    NCBI Gene ID: 554213

  • Chr Location
    chr5:55170532-55170622 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    10 phenotype references
Mice homozygous for a null allele are normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
genomic 723868 NCBI Gene Model | MGI Sequence Detail 91 C57BL/6J ±  kb
transcript NR_029961 RefSeq | MGI Sequence Detail 91 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 8
    cDNA 1
    Primer pair 2
    Other 5
Other Database
Links
less
miRBase MI0001649
References
more
  • Summaries
    All 35
    Developmental Gene Expression 12
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
  • Latest
    J:349837 Liu H, et al., A local translation program regulates centriole amplification in the airway epithelium. Sci Rep. 2023 May 1;13(1):7090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory