Mir449a MGI Mouse Gene Detail - MGI:3619407

Symbol

Mir449a
Name

microRNA 449a
Synonyms

mir 449, Mirn449a, mmu-mir-449a

Feature Type

miRNA gene
IDs

MGI:3619407
NCBI Gene: 723868
Member of

Mirc34 cluster
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:113174068-113174158 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 63.93 cM
Mapping Data

1 experiment

SNPs within 2kb

108 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3619407	miRNA gene	Chr13:113174068-113174158 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0008100	miRNA gene	Chr13:115644659-115644749 (+)
A/J	MGP_AJ_G0008088	miRNA gene	Chr13:111018166-111018256 (+)
AKR/J	MGP_AKRJ_G0008068	miRNA gene	Chr13:114368252-114368342 (+)
BALB/cJ	MGP_BALBcJ_G0008070	miRNA gene	Chr13:111713760-111713850 (+)
C3H/HeJ	MGP_C3HHeJ_G0008014	miRNA gene	Chr13:114160848-114160938 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008257	miRNA gene	Chr13:119065995-119066085 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007354	miRNA gene	Chr13:106308474-106308564 (+)
CAST/EiJ	MGP_CASTEiJ_G0007894	miRNA gene	Chr13:113800167-113800257 (+)
CBA/J	MGP_CBAJ_G0007982	miRNA gene	Chr13:123672491-123672581 (+)
DBA/2J	MGP_DBA2J_G0008017	miRNA gene	Chr13:110729620-110729710 (+)
FVB/NJ	MGP_FVBNJ_G0008041	miRNA gene	Chr13:109430924-109431014 (+)
LP/J	MGP_LPJ_G0008100	miRNA gene	Chr13:115678306-115678396 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0008009	miRNA gene	Chr13:123926712-123926802 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008255	miRNA gene	Chr13:113833792-113833882 (+)
PWK/PhJ	MGP_PWKPhJ_G0007814	miRNA gene	Chr13:109479905-109479995 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007711	miRNA gene	Chr13:110147889-110147979 (+)
WSB/EiJ	MGP_WSBEiJ_G0007968	miRNA gene	Chr13:114430421-114430511 (+)

Human Ortholog

MIR449A, microRNA 449a

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR449A, microRNA 449a
Synonyms

hsa-mir-449, mir-449a, MIRN449, MIRN449A
Links

HGNC:27645

NCBI Gene ID: 554213
Chr Location

chr5:55170532-55170622 (-) GRCh38

MGI Vertebrate Homology

Mir449a stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR449A
Gene Tree

Mir449a

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Phenotype Summary

1 phenotype from 2 alleles in 1 genetic background
10 phenotype references

All Mutations and Alleles

7
Endonuclease-mediated

4
Targeted

3
Genomic Mutations

2 involving Mir449a
Find Mice (IMSR)

2 strains or lines available

Mice homozygous for a null allele are normal.

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All GO Annotations

26
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

34
cDNA Data

1
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000065575 (Evidence)
NCBI Gene

723868

Representative Sequences				Length	Strain/Species	Flank
	genomic	723868	NCBI Gene Model \| MGI Sequence Detail	91	C57BL/6J	± kb
	transcript	NR_029961	RefSeq \| MGI Sequence Detail	91	C57BL/6

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All nucleic 8

cDNA 1

Primer pair 2

Other 5

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miRBase

MI0001649

Summaries

All 35

Developmental Gene Expression 12

Gene Ontology 3

Phenotypes 10
Earliest

J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
Latest

J:349837 Liu H, et al., A local translation program regulates centriole amplification in the airway epithelium. Sci Rep. 2023 May 1;13(1):7090

TSS for Mir449a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121166	Chr13:113174144-113174148 (+)	78 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24