Tg(Myl2-FGF19)1Dfre
Transgene Detail

Summary

• Symbol: Tg(Myl2-FGF19)1Dfre
• Name: transgene insertion 1, Dorothy M French
• MGI ID: MGI:3510921
• Synonyms: FGF19, MLC-FGFG19
• Transgene: Tg(Myl2-FGF19)1Dfre Location: unknown
• Alliance: Tg(Myl2-FGF19)1Dfre page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myl2-FGF19)1Dfre expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGF19 (9965)

  Fgf15

  (MGI:1096383)

• Mutation details: The human FGF19 cDNA was ligated to a rat myosin light chain 2 promoter and followed by the splice donor/acceptor sites present between exons 4 and 5 of the human growth hormaone gene. RT-PCR analysis of skeletal muscle biopsies showed the presence of human transcript in transgenic mice. Transgenic protein was verified by enzyme-linked immunosorbent assay. This record is a representative transgene as founder lines were not named. (J:76323)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76323 Tomlinson E, et al., Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology. 2002 May;143(5):1741-7
• All: 5 reference(s)