Tg(Ela1-TAg)19Bri
Transgene Detail

Summary

• Symbol: Tg(Ela1-TAg)19Bri
• Name: transgene insertion 19, Ralph L Brinster
• MGI ID: MGI:2655223
• Synonyms: EL-TAg, line 264-4, Tg(Ela-1, SV40E + Ela-1, neo)Bri19
• Transgene: Tg(Ela1-TAg)19Bri Location: unknown
• Alliance: Tg(Ela1-TAg)19Bri page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgenic construct contained 7.2 kb of the rat Ela1 promoter region adjoined to sequence encoding SV40 small and large T antigens. The promoter was used to drive transgenic expression in pancreatic acinar cells. (J:80845)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ela1-TAg)19Bri

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

The founder line contained 8 copies of the transgenic construct.

References

• Original: J:80845 Ornitz DM, et al., Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science. 1987 Oct 9;238(4824):188-93
• All: 3 reference(s)