Tg(ITGAM-HBEGF/EGFP)34Lan
Transgene Detail

Summary

• Symbol: Tg(ITGAM-HBEGF/EGFP)34Lan
• Name: transgene insertion 34, Richard A Lang
• MGI ID: MGI:3574313
• Synonyms: CD11b-DTR, tg(CD11b-DTR)Llan, Tg(ITGAM-DTR/EGFP)34Lan
• Transgene: Tg(ITGAM-HBEGF/EGFP)34Lan Location: unknown
• Alliance: Tg(ITGAM-HBEGF/EGFP)34Lan page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ITGAM-HBEGF/EGFP)34Lan expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  monkey	HBEGF

• Mutation details: The transgene contains a fusion product involving simian diphtheria toxin receptor and green fluorescent protein under the control of the human ITGAM (integrin alpha M) promoter (CD11b), and human growth hormone sequence. Mice carrying this transgene have a diphtheria toxin (DT) inducible system that transiently depletes macrophages. RT-PCR analysis of bone marrow macrophages detects specific transgene expression. (J:95141)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:95141 Duffield JS, et al., Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest. 2005 Jan;115(1):56-65
• All: 78 reference(s)