Tg(KRT14-CASP1)1Miz
Transgene Detail

Summary

• Symbol: Tg(KRT14-CASP1)1Miz
• Name: transgene insertion 1, Hitoshi Mizutani
• MGI ID: MGI:2388821
• Synonyms: KCASP1Tg
• Transgene: Tg(KRT14-CASP1)1Miz Location: unknown
• Alliance: Tg(KRT14-CASP1)1Miz page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-CASP1)1Miz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CASP1 (834)

  Casp1

  (MGI:96544)

• Mutation details: 1.4 kb CASP1 cDNA was adjoined to the human keratin 14 (KRT14) promoter and rabbit beta-globin intron. The human keratin 14 promoter drives expression in epidermal tissue. Expression analysis showed transgenic expression in the skin, but not in liver, kidney, colon, lung, brain, or spleen tissue. (J:79706)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:79706 Yamanaka K, et al., Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J Immunol. 2000 Jul 15;165(2):997-1003
• All: 6 reference(s)