Tg(tetO-MYC)1Lach
Transgene Detail

Summary

• Symbol: Tg(tetO-MYC)1Lach
• Name: transgene insertion 1, Lewis A Chodosh
• MGI ID: MGI:3531157
• Synonyms: Tg(MYC)1lach, TOM, TRE-Myc
• Transgene: Tg(tetO-MYC)1Lach Location: unknown
• Alliance: Tg(tetO-MYC)1Lach page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-MYC)1Lach expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: This transgene contains exons 2 and 3 of the human v-myc avian myelocytomatosis viral oncogene homolog gene and and regulatory elements from the bacterial tetracycline-resistance operon. (J:67498)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-MYC)1Lach

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:67498 D'Cruz CM, et al., c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med. 2001 Feb;7(2):235-9
• All: 22 reference(s)